Influence of lycopene and anthocyanin as protective and curative agents on male and female albino rats treated with dexamethasone for seven weeks were studied on liver function (AST & ALT), kidney function (s. creatinine) and body weights. Results reveal that dexamethasone induce bodyweight loss. However, higher levels of AST & ALT and s. creatinine were measured after dexamethasone treatment. On the other hand, the application of lycopene and anthocyanin as natural antioxidant extracted from peel wastes of Tomato and Pomegranate resulted in revised effect of higher levels of AST, ALT, s. creatinine compared to positive and normal control groups. Meanwhile body weights loss that happen after dexamethasone treatment show slight improve compared to dexamethasone control positive group. These results reveal that both lycopene and anthocyanin could be applied either protective or curative valuable powerful available cheap substances to face undesirable side effects of oxidative stress induced as consequences dexamethasone treatment.