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379085

INVESTIGATION OF ANTICANCER MECHANISMS OF A CHALCONE/XANTHINE HYBRID IN NON-SMALL CELL LUNG CANCER

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Last updated: 04 Jan 2025

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Abstract

Despite major advances in therapy, Lung cancer remains the major cause of death among cancer cases. Chalcone/xanthine Hybrid is a synthetic xanthine derivative that was found to exert an anticancer action in various cancer types. Thus, the current study sought to discover if the chalcone/xanthine hybrid influences the etiology of non-small cell lung cancer (NSCLC). We found that the chalcone/xanthine hybrid inhibited cell cycle progression while inducing apoptosis and causing arrest of the cell cycle in HOP-92 cells. Flow cytometry demonstrated that chalcone/xanthine hybrid strongly induced apoptosis in HOP-92 cells, as well as alterations in apoptosis-related protein expression, including an increase in Bax, caspase3, caspase8, caspase-9, P53 expression, as well as a decrease in Bcl-2 expression.

Moreover, the chalcone/xanthine hybrid slowed cell cycle progression from the G1 phase to the S phase. Furthermore, the ratio of phosphorylated proteins (AKT, MEK, ERKĀ½, and P38) to total protein quantity reduced, indicating regulation of downstream protein signaling pathways governing cell cycle growth. Overall, this chalcone/xanthine hybrid may be considered a therapeutic option for NSCLC via apoptosis induction.

DOI

10.21608/bfsa.2024.305647.2224

Keywords

NSCLC (non-small cell lung cancer), HOP-92 (Hopkins-92), MAPK (mitogen activated protein kinase)

Authors

First Name

Omar

Last Name

Elrehany

MiddleName

Mahmoud

Affiliation

Department of Biochemistry, Faculty of pharmacy, Minia University, Minya, Egypt

Email

o_elrehany@yahoo.com

City

Minya

Orcid

-

First Name

Al - Shaimaa

Last Name

Ahmed

MiddleName

Faissal

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University

Email

shaimaa.faissal@minia.edu.eg

City

Minia

Orcid

-

First Name

Hesham

Last Name

Abou-Zied

MiddleName

A.

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt

Email

hisham.alaa@deraya.edu.eg

City

Minia

Orcid

0000-0001-6993-3325

First Name

Alaa

Last Name

Hayallah

MiddleName

M.

Affiliation

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Assiut, Egypt, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sphinx University, New Assiut, Egypt

Email

alaa_hayalah@yahoo.com

City

Assiut

Orcid

0000-0001-9517-8650

First Name

Mohamed

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

abulnil@hotmail.com

City

Minia

Orcid

0000-0003-1396-8662

First Name

Maiiada

Last Name

Nazmy

MiddleName

Hassan

Affiliation

Department of Biochemistry, Faculty of pharmacy, Minia University, Minya, Egypt

Email

maiiada_nazmy@mu.edu.eg

City

minya

Orcid

-

Volume

47

Article Issue

2

Related Issue

51758

Issue Date

2024-12-01

Receive Date

2024-08-01

Publish Date

2024-12-01

Page Start

1,353

Page End

1,366

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 2_Pages 1353-1366.pdf

PDF . 908.4kB

Link

https://bpsa.journals.ekb.eg/article_379085.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=379085

Order

379,085

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INVESTIGATION OF ANTICANCER MECHANISMS OF A CHALCONE/XANTHINE HYBRID IN NON-SMALL CELL LUNG CANCER

Details

Type

Article

Created At

25 Dec 2024