This study investigated the effects of Annona muricata leaf ethanol extract on the haematological and biochemical indices in rat testosterone-induced benign prostatic hyperplasia (BPH). Thirty male Wistar rats with average weight of 90g were divided into six groups (n=5): normal control (NC), testosterone-induced negative control (TC), Finasteride treatment control (FT; 0.5mg/kg b.w), and the A. muricata treatment low (100 mg/kg), medium (200 mg/kg) and high (400 mg/kg) b.w doses denoted as AML, AMM and AMH respectively. BPH was induced by s.c injection of testosterone propionate for 28 consecutive days. Oral treatments with finasteride and extract doses followed for 14 days. Results showed n-hexadecanoic with highest abundance (32.60%) using GC-MS. Leukocytosis, platelet aggregation, hyperlipidemia and hyperuricemia were significant observations in the TC. The extract doses significantly (p<0.05) modulated these states. This work suggests that the multiple therapeutic properties of A. muricata could serve as a safe, multifactorial treatment approach against BPH.