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384406

THE PROTECTIVE EFFECTS OF TOCOTRIENOLS AND COENZYME Q10 AGAINST GLUCOCORTICOID-INDUCED OSTEOPOROSIS IN RATS: POTENTIAL ROLES OF NRF2, BCL-2, AND AUTOPHAGY

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Last updated: 25 Dec 2024

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Abstract

Glucocorticoid use is the main cause of secondary osteoporosis. This study aimed to assess the potential protective effects of tocotrienols (T) and CoQ10(C), singly and in combination, against dexamethasone (DEX)-induced osteoporosis in rats and their possible mechanisms. Thirty adult male albino rats were divided into five groups: control group (CON), DEX-treated group received DEX (2.5 mg/kg) intramuscularly twice weekly. The DEX+C, DEX+T, and DEX+TC groups received DEX with T (60 mg/kg), C (20 mg/kg) daily, and their combination respectively, daily orally for 8 weeks. Results revealed that T, C and TC ameliorated DEX-induced osteoporosis through improved osteocalcin (OC), alkaline phosphatase (ALP), Ca and TAC serum levels. Restoration of the expression levels of Nrf2, LC3, and Bcl-2 and improved histological structure of the bones were observed. The combination of the drugs was more effective than each single agent. Both drugs might be promising agents as prophylaxis against osteoporosis via suppressing oxidative stress and apoptosis and enhancing autophagy.

DOI

10.21608/bfsa.2024.309021.2223

Keywords

DEX, OC, ALP, TAC

Authors

First Name

Alaa

Last Name

Abdelhafez

MiddleName

T.

Affiliation

Department of Pharmacology Faculty of Medicine Assiut University

Email

alaa.abdelhafez@aun.edu.eg

City

-

Orcid

-

First Name

• Asmaa

Last Name

Gomaa

MiddleName

M.S.

Affiliation

Department of Physiology Faculty of Medicine Assiut University, College of Medicine, Jouf University, Sakaka 723388, Saudi Arabia.

Email

asmaagom3a@aun.edu.eg

City

-

Orcid

-

First Name

Asmaa

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Pathology Faculty of Medicine Assiut University

Email

drasmaamhm@aun.edu.eg

City

-

Orcid

-

First Name

Manal

Last Name

Sayed

MiddleName

M.

Affiliation

Department of Histology Faculty of Medicine Assiut University

Email

manalgomea@aun.edu.eg

City

-

Orcid

-

First Name

• Tohamy

Last Name

Tohamy

MiddleName

Anwar

Affiliation

Faculty of Science Assiut University

Email

tohamy.anwar@scenise.edu.aun.eg

City

-

Orcid

-

First Name

• Mai

Last Name

Abd_Elkareem Ali

MiddleName

Assem

Affiliation

Faculty of Medicine Assiut University

Email

mai.14224122@med.aun.edu.eg

City

-

Orcid

-

First Name

Sally

Last Name

Sayed

MiddleName

A.

Affiliation

Department of physiology, Faculty of Medicine, Assiut University, Badr University Assiut (BUA), Egypt.

Email

sallyanw19@aun.edu.eg

City

-

Orcid

-

Volume

47

Article Issue

2

Related Issue

51758

Issue Date

2024-12-01

Receive Date

2024-08-01

Publish Date

2024-12-01

Page Start

1,297

Page End

1,310

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 2_Pages 1297-1310.pdf

PDF . 1.6MB

Link

https://bpsa.journals.ekb.eg/article_384406.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=384406

Order

384,406

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE PROTECTIVE EFFECTS OF TOCOTRIENOLS AND COENZYME Q10 AGAINST GLUCOCORTICOID-INDUCED OSTEOPOROSIS IN RATS: POTENTIAL ROLES OF NRF2, BCL-2, AND AUTOPHAGY

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Article

Created At

25 Dec 2024