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384496

CYMBOPOGON CITRATUS: A MODULATOR OF TNF-Α AND IL-10 IN NSAID-INDUCED HEPATORENAL TOXICITY IN ADULT WISTAR RATS

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Last updated: 25 Dec 2024

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Abstract

Pharmaceuticals typically induce toxicity in the liver and kidney, which are primary control mechanisms for maintaining bodily homeostasis and are more vulnerable to xenobiotics. Cymbopogon citratus (West Indian lemon grass) is used in traditional medicine globally for a variety of medicinal purposes. This study aimed to determine the therapeutic effectiveness of a methanolic leaf extract of C. citratus against NSAID-induced hepatorenal toxicity in adult Wistar rats (Rattus norvegicus domestica). Twenty rats weighing 180–220g were randomly assigned to four groups of five rats each. The unexposed control rats (Group 1) were administered distilled water, while the NSAID-exposed rats (Group 2-4) received Diclofenac at 5mg/kg/BW. While rats in Group 2 were untreated, rats in Groups 3 and 4 were treated with methanolic leaf extracts of C. citratus at 100mg/kg/BW and 200mg/kg/BW, respectively. Treatment with the methanolic extract of C. citratus modulates TNF-α and IL-10 expression (P<0.05) and ameliorates cellular alterations in the kidneys and liver of treated rats compared to the untreated group. This study established the efficacy of Cymbopogon citratus as a hepatorenal protector by considerably ameliorating the adverse effects of diclofenac-induced hepatorenal toxicity.

DOI

10.21608/bfsa.2024.297319.2162

Keywords

Cytokines, Health, phytochemicals, Rats, toxicity

Authors

First Name

Akinpelu

Last Name

MORONKEJI

MiddleName

-

Affiliation

Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Medical Sciences Ondo, Ondo State, Nigeria.

Email

amoronkeji@unimed.edu.ng

City

Ondo

Orcid

0000-0001-5186-8676

First Name

Temidayo

Last Name

Adeniyi

MiddleName

D

Affiliation

Department of Medical Laboratory Science, College of Health Sciences, University of Ilorin, Kwara State Nigeria.

Email

adeniyi.td@unilorin.edu.ng

City

Kwars

Orcid

0000-0002-8482-9136

First Name

Abiodun

Last Name

Oyeleke

MiddleName

-

Affiliation

Department of Anatomy, Federal University Oye-Ekiti, Ekiti State, Nigeria

Email

abiodun.oyeleke@fuoye.edu.ng

City

-

Orcid

0000-0001-5688-7016

First Name

Chuks

Last Name

Igunbor

MiddleName

M

Affiliation

Department of Medical Laboratory Science, Achievers University Owo, Ondo State, Nigeria

Email

igunbor.mc@achievers.edu.ng

City

-

Orcid

-

First Name

Joy

Last Name

AYENI

MiddleName

Olajumoke

Affiliation

Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Medical Sciences Ondo, Ondo State, Nigeria.

Email

joyolajumoke1@gmail.com

City

Ondo

Orcid

-

First Name

Toluwanimi

Last Name

ADELABI

MiddleName

Olanike

Affiliation

Department of Medical Laboratory Science, Faculty of Allied Health Sciences University of Medical Sciences Ondo, Nigeria.

Email

tolunike2003@gmail.com

City

-

Orcid

-

First Name

Adebimpe

Last Name

Moronkeji

MiddleName

-

Affiliation

Department of Medical Laboratory Science, Elizade University Ilara Mokin, Ondo State Nigeria.

Email

moronkejibimpe@gmail.com

City

-

Orcid

-

Volume

47

Article Issue

2

Related Issue

51758

Issue Date

2024-12-01

Receive Date

2024-06-12

Publish Date

2024-12-01

Page Start

1,251

Page End

1,262

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 2_Pages 1251-1262.pdf

PDF . 951.4kB

Link

https://bpsa.journals.ekb.eg/article_384496.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=384496

Order

384,496

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CYMBOPOGON CITRATUS: A MODULATOR OF TNF-Α AND IL-10 IN NSAID-INDUCED HEPATORENAL TOXICITY IN ADULT WISTAR RATS

Details

Type

Article

Created At

25 Dec 2024