Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Ethanol-induced GU in animal model resembles the pathophysiology of human ulcer. The aim of this research was to examine the antioxidant properties of esomeprazole, curcumin, chitosan, and a mixture from curcumin and chitosan on gastric ulcers produced by ethanol in rats. The research included 60 animal, with an average weight between (179.60 - 180.30) gm. The rats were divided into a control group and five treated groups, each containing 10 rats. The treated groups received 0.1M acetic acid, esomeprazole, curcumin, chitosan, and curcumin – chitosan mixture. All groups were treated for a duration of 30 days. Following the conclusion of the experiment, the body was weighed both before to and subsequent to its completion. In order to develop stomach ulcers, a dose of 2 ml of absolute ethanol was administered orally to all groups, with the exception of the negative control group, after a 20-hour fasting interval. Subsequently, all the animals were euthanized 5 hours later. The study of gastric ulceration included a comparison of the amount and pH of gastric juice, ulcer index, protective index, and macroscopic inspection of the stomach. The research used gastric tissue homogenate to measure several parameters, including the quantity of MDA, the activity of SOD, and the concentration of NO.