Background: Potentially increased admissions to hospitals and morbidity may be associated with poor asthma care plans and treatment. Adolescents and children with asthma have been the target of numerous initiatives aimed at improving or maintaining treatment adherence.

Objective: The purpose of this research was to examine the effect of various interventions on patients' compliance with using asthma controller inhalers.

Methods: Studies published up until August 2022 were thoroughly searched for in four databases: Embase, Web of Science, the Cochrane Central Register of Controlled Trials, and PubMed. The data was collected and examined.

Results: The analysis comprised an overall of 39 studies. Asthma educational training sessions, texting reminders, and electronic feedback were among the many interventions found. A minor but significant impact size of 0.37 [95%CI, 0.20, 0.55, P-value <0.001] was produced by the overall effectiveness of the therapies in comparison to the control group. With a cumulative effect size of 0.75 [95% CI, 0.43, 1.06, P-value<0.001], electronic surveillance was statistically significantly better than both pharmacy refills and self-reporting.

Conclusions: Promotional programs aimed at adherence are successful among adolescents diagnosed with asthma. The use of electronic monitoring methods has shown to be superior and successful in enhancing patient compliance with asthma inhalers. Further longitudinal research is required to assess cost-efficiency and quantify a more accurate estimate of the effectiveness of the interventional approach employed over time.