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EXPLORING THE POTENTIAL HEPATOPROTECTIVE EFFICACY OF LEPIDIUM SATIVUM SEEDS: A COMPREHENSIVE REVIEW

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Last updated: 25 Dec 2024

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Abstract

Abstract: Background: Chronic liver diseases are the leading cause of morbidity and mortality worldwide.Lepidium sativum (L. sativum) is a famous member of the Bras-sicaceae family that has been utilized for medicinal and culinary purposes for cen-turies. The hepatoprotective activity of various portions of the plant has been re-ported in several experimental and clinical trials. Aim: The current review study aimed to discuss the hepatoprotective effects of L. sativum seeds. Methods: The da-ta of this review were collected from English-language in-vivo and in-vitro studies published in electronic databases; with no time limit; including Web of Science, Scopus, MEDLINE, Google Scholar and PubMed. The searched keywords were “Lepidium sativum" and/or “chemical composition", “Hepatoprotective", “liver diseases". Results: Lepidium sativum seeds significantly decreased the elevated in-flammatory markers and oxidative stress in hepatic tissues. The seed extract signifi-cantly lowered serum levels of ASP, ALT, and bilirubin. The potential molecular mechanism may be through upregulating Bcl-2 protein expression and downregu-lating caspase-3. Conclusion: Lepidium sativum seeds are promising hepatoprotec-tive natural remedy through their multi-targeted action on different pathophysio-logical mechanisms involved in liver diseases.

DOI

10.21608/bfsa.2024.276705.2061

Keywords

Lepidium sativum, secondary metabolites, Hepatoprotective

Authors

First Name

Eman.

Last Name

Sawan

MiddleName

S

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

eman.said@buc.edu.eg

City

-

Orcid

-

First Name

Alaa

Last Name

Abdelhadi

MiddleName

A.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

alaa_ashraf@buc.edu.eg

City

-

Orcid

-

First Name

Kareem

Last Name

Elsyed

MiddleName

H.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

karim.20190929@buc.edu.eg

City

-

Orcid

-

First Name

Nora

Last Name

Elsayed

MiddleName

H.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

nora.20193711@buc.edu.eg

City

-

Orcid

-

First Name

Heba

Last Name

Yassen

MiddleName

R.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

heba.20192145@buc.edu.eg

City

-

Orcid

-

First Name

Manar

Last Name

Mohammed

MiddleName

R.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

manar.20192722@buc.edu.eg

City

-

Orcid

-

First Name

Nadeen.

Last Name

Ahmed

MiddleName

S.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

nadeen.20193326@buc.edu.eg

City

-

Orcid

-

First Name

Manar

Last Name

Zahran

MiddleName

K.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

manar.20196058@buc.edu.eg

City

-

Orcid

-

First Name

Nada

Last Name

Elkest

MiddleName

M.

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

nada.20190710@buc.edu.eg

City

-

Orcid

-

First Name

Omar

Last Name

Hammad

MiddleName

-

Affiliation

Under graduate Students at Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829, Egypt

Email

omr.20190379@buc.edu.eg

City

-

Orcid

-

First Name

Shimaa

Last Name

Shimaa Abdelsattar

MiddleName

-

Affiliation

Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menofia University

Email

shimaa.abdelsattar@liver.menofia.edu.eg

City

-

Orcid

-

First Name

Raghda

Last Name

Hussein

MiddleName

-

Affiliation

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

Email

raghda.hussien@pharm.bsu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Latif

MiddleName

M.

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University

Email

m.abdellatif@aun.edu.eg

City

Assiut, Egypt

Orcid

-

First Name

Shaza

Last Name

Aly

MiddleName

H.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City 11829

Email

shaza.husseiny@buc.edu.eg

City

-

Orcid

-

Volume

47

Article Issue

2

Related Issue

51758

Issue Date

2024-12-01

Receive Date

2024-03-13

Publish Date

2024-12-01

Page Start

1,119

Page End

1,135

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 2_Pages 1119-1135.pdf

PDF . 1.0MB

Link

https://bpsa.journals.ekb.eg/article_352746.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=352746

Order

352,746

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EXPLORING THE POTENTIAL HEPATOPROTECTIVE EFFICACY OF LEPIDIUM SATIVUM SEEDS: A COMPREHENSIVE REVIEW

Details

Type

Article

Created At

25 Dec 2024