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355783

GC-MS ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTICANCER, CYTOTOXICITY, AND HYPOGLYCEMIC PROPERTIES OF THE LIBYAN MORINGA OLEIFERA LEAF EXTRACT ON ALLOXAN-INDUCED DIABETES IN MICE

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Last updated: 25 Dec 2024

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Abstract

Libyan Moringa oleifera leaves were extracted using methanol, and the bioactive components' antibacterial, antioxidant, anti-inflammatory, and anticancer characteristics were assessed using gas chromatography mass spectrometry analysis (GC-MS). Moringa oleifera exhibited antioxidant activity, with an IC50 of 11.53 µg/mL. Wi38 cell line's viability decreased with increasing M. oleifera extract concentration, while its cytotoxicity increased with an IC50 of 393.41±7.77 μg/mL. Alloxan-induced diabetes model in Swiss albino mice was implemented. Three different doses (100, 200, or 300 mg/kg of mice body weight) of M. oleifera's extract were evaluated for their effects on blood sugar concentration and the histology of the pancreatic islets. The normoglycemic group did not experience hypoglycemia as a result of the extract intake. Blood glucose levels were noticeably lower at 200 and 300 mg/kg, especially with the 300 mg/kg dose. The 300 mg/kg dose considerably decreased the fasting blood sugar by the fourth week without endangering hypoglycemia. Giving 100 and 200 mg/kg of M. oleifera extract to the diabetic control group resulted in varied alloxan attack recovery and regeneration of islet and acin. The morphology and acini of the pancreatic islets underwent a significant modification following the ingestion of 300 mg/kg of M. oleifera extract. They were notably bigger and more revitalized, and the number of β-cells that adopted a spherical shape significantly increased.

DOI

10.21608/bfsa.2024.268613.2039

Keywords

Antimicrobial, antioxidant, Anticancer, diabetic, Moringa

Authors

First Name

Osama

Last Name

Al-Bedak

MiddleName

Abdel-Hafeez Mohamed

Affiliation

Assiut University Mycological Centre, Assiut University

Email

osamaalbedak@science.au.edu.eg

City

Assiut

Orcid

0000-0003-0465-619X

First Name

Ahlam

Last Name

Rashed

MiddleName

-

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

a.rashed@zu.edu.ly

City

-

Orcid

0000-0002-0616-0924

First Name

Seham

Last Name

Oshkondali

MiddleName

T.M.

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

s.oshkondali@zu.edu.ly

City

-

Orcid

0009-0001-3397-1159

First Name

Nouri

Last Name

Kushlaf

MiddleName

-

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

n.kushlaf@zu.edu.ly

City

-

Orcid

0009-0001-4634-5747

First Name

Amal

Last Name

Elshebani

MiddleName

-

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

a.alshebani@zu.edu.ly

City

-

Orcid

0000-0003-1149-4803

First Name

Samira

Last Name

Alacrouk

MiddleName

A.

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

s.alacrouk@zu.edu.ly

City

-

Orcid

0000-0003-1029-4711

First Name

Fadia

Last Name

Oshkondale

MiddleName

T.M.

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

f.oshkondale@zu.edu.ly

City

-

Orcid

0009-0008-2792-2343

First Name

Manal

Last Name

Elsheli

MiddleName

-

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

m.elshilli@zu.edu.ly

City

-

Orcid

0009-0003-6003-9388

First Name

Zuhur

Last Name

Almesai

MiddleName

R.

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

pg014200441@zu.edu.ly

City

-

Orcid

0000-0003-0009-1152

First Name

Ameerah

Last Name

Shaeroun

MiddleName

-

Affiliation

The Advanced Center for Plant Research and Complementary Medicine, Zawia University; Zawia, Libya

Email

a.shaeroun@zu.edu.ly

City

-

Orcid

0009-0003-3338-7635

First Name

Steven

Last Name

Stephenson

MiddleName

L.

Affiliation

Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701, USA

Email

slsteph@uark.edu

City

-

Orcid

0000-0002-9207-8037

First Name

Fuad

Last Name

Ameen

MiddleName

-

Affiliation

Department of Botany & Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

Email

fuadameen@ksa.edu.sa

City

-

Orcid

0000-0002-5185-022X

Volume

47

Article Issue

2

Related Issue

51758

Issue Date

2024-12-01

Receive Date

2024-02-19

Publish Date

2024-12-01

Page Start

837

Page End

852

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 2_Pages 837-852.pdf

PDF . 1.5MB

Link

https://bpsa.journals.ekb.eg/article_355783.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=355783

Order

355,783

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

GC-MS ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTICANCER, CYTOTOXICITY, AND HYPOGLYCEMIC PROPERTIES OF THE LIBYAN MORINGA OLEIFERA LEAF EXTRACT ON ALLOXAN-INDUCED DIABETES IN MICE

Details

Type

Article

Created At

25 Dec 2024