The integumentary system, mostly made up of skin tissue, is the most substantial system in the human skeleton, serving as an essential shield against a myriad of detrimental agents. These include but are not limited to, toxic chemicals, pervasive environmental pollutants, and the deleterious effects of ultraviolet radiation. The senescence of the dermis and epidermis is an inexorable biological phenomenon, subject to a multitude of contributing factors. Ultraviolet radiation, nutritional habits, aridity, tobacco consumption, hormonal fluctuations, and the force of gravity all play pivotal roles in this complex process. Dermatological aging manifests in two distinct forms: intrinsic aging, an unavoidable consequence of the passage of time that remains impervious to intervention; and extrinsic aging or photoaging, which owes its occurrence predominantly to environmental insults. As skin ages, it loses vital components such as elastin, collagen, and proteins that are essential for maintaining healthy skin. Currently, numerous skincare routines and methods are available to rejuvenate aged skin and prevent further aging. Antiaging strategies can be divided into preventive measures and secondary antiaging approaches. Tretinoin, in particular, is a topical retinoid that has been proven effective as an antiaging agent for treating conditions like acne, wrinkles, and melasma. However, the effectiveness of retinoids is often challenged by issues such as instability, low skin penetration, and potential irritation. To address these drawbacks associated with traditional retinoids like tretinoin and retinol, nanotechnology-based topical drug delivery systems have been developed. These advanced systems have demonstrated improved stability, better tolerability, and enhanced efficacy of retinoids.