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359286

RECENT ADVANCES OF Β-BLOCKERS AS DRUG REPURPOSING APPROACH: A SYSTEMATIC REVIEW

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Last updated: 04 Jan 2025

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Abstract

Repurposing pharmaceuticals is a potentially effective method in drug development to find novel therapeutic applications for already FDA-approved medications that deviate from their original intended usage. Compared with conventional methods of de novo drug discovery, it offers numerous benefits because it can drastically cut down on development time and medical expenses. In this review, the potential repurposing of β-blockers that have been previously authorized by the FDA for the management of cardiovascular disorders such as (hypertension, arrhythmias, and aortic dissection) was discussed. β-blockers have been shown to have encouraging anti-cancer, antibacterial, antimigraine, and spermicide properties in many experimental and epidemiological investigations. The outcomes have led to new drug indications or may lead to new drug indications. The objective of this review is to collect medications and their plausible modes of action that support repurposing, address difficulties in repositioning β-blockers for other disorders, and explore the possible therapeutic benefits of incorporating these medicines into nano-system formulations.

DOI

10.21608/bfsa.2024.283788.2091

Keywords

Drug repurposing, Anti-Hypertensive, B-blockers, Nano-systems

Authors

First Name

Moaz

Last Name

A. Eltabeeb

MiddleName

-

Affiliation

Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt

Email

moaz.eltabib@must.edu.eg

City

Giza

Orcid

-

First Name

Raghda

Last Name

Rabe Hamed

MiddleName

-

Affiliation

Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt

Email

raghda.hamid@must.edu.eg

City

Giza

Orcid

-

First Name

Mohamed

Last Name

A. El-Nabarawi

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

mohamed.elnabarawi@pharma.cu.edu.eg

City

Cairo

Orcid

-

First Name

Mahmoud

Last Name

H. Teaima

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

mahmoud.teaima@pharma.cu.edu.eg

City

Cairo

Orcid

-

First Name

Menna

Last Name

M. Abdellatif

MiddleName

-

Affiliation

Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt

Email

menna.abdallatif@must.edu.eg

City

Giza

Orcid

-

Volume

47

Article Issue

2

Related Issue

51758

Issue Date

2024-12-01

Receive Date

2024-04-19

Publish Date

2024-12-01

Page Start

681

Page End

698

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 2_Pages 681-698.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_359286.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=359286

Order

359,286

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RECENT ADVANCES OF Β-BLOCKERS AS DRUG REPURPOSING APPROACH: A SYSTEMATIC REVIEW

Details

Type

Article

Created At

25 Dec 2024