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349973

THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES

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Last updated: 04 Jan 2025

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Abstract

The majority of studies on Novel Mucosal-associated invariant T (MAIT) cells have focused on their involvement in solid tumours; however, the role and significance of MAIT cells in hematological malignancies are not well understood and have not been thoroughly investigated. MAIT cells is a population of αβ T cells that recognize non-peptide antigens presented by the non-polymorphic MR1 molecule. They are characterized by the expression of Vα7.2 together with high expression of the CD161. MAIT cells have been linked to a variety of tumours including, solid tumours such as hepatocellular carcinoma, colorectal, lung and kidney cancers and their frequencies in the tumour sites appeared to correlate with prognosis. MAIT cells were also studied in hematological malignancies such as multiple myeloma and leukaemia. In this review we will outline our current understanding of the relationship between MAIT cells and hematological malignancies, which will underline the possibility of targeting this subset for modern immunotherapy development.

DOI

10.21608/bfsa.2024.272271.2041

Keywords

MAIT cells, Acute myeloid leukemia (AML), Vα 7.2, IFN, GrB and Immunotherapy

Authors

First Name

Ali

Last Name

Ahmed

MiddleName

A

Affiliation

Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

aliabdelhafiz@pharm.aun.edu.eg

City

-

Orcid

-

First Name

Omnia

Last Name

Bakr Badawy

MiddleName

Hasan

Affiliation

Department of Medical Microbiology and Immunology, Faculty of medicine, Assiut University, Assiut, Egypt

Email

omniaalbadawy@aun.edu.eg

City

Assiut

Orcid

-

First Name

Mohamed

Last Name

El Mokhtar

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt, Gilbert & Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon

Email

elmokhtarma@aun.edu.eg

City

-

Orcid

0000-0003-2500-0480

First Name

Omer A

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pharmacy, Al-Mansha Central Hospital, Sohag Health Directorate, Sohag, Egypt

Email

omer.abdel-haffeez@msa.edu.eg

City

-

Orcid

-

First Name

Marwa

Last Name

Sabet

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Sphinx University, New-Assiut, Egypt

Email

marwa.sabet@sphinx.edu.eg

City

-

Orcid

-

First Name

A

Last Name

Zahran

MiddleName

M

Affiliation

Department of clinical pathology, South Egypt cancer Institute, Assiut, University, Assiut 71515, Egypt.

Email

zahranam@aun.edu.eg

City

Assiut

Orcid

-

First Name

Salwa

Last Name

Seif Eldin

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of medicine, Assiut University, Assiut, Egypt

Email

salwaseifeldein@aun.edu.eg

City

-

Orcid

-

Volume

47

Article Issue

1

Related Issue

47734

Issue Date

2024-06-01

Receive Date

2024-02-23

Publish Date

2024-06-01

Page Start

571

Page End

584

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 1_Pages 571-584.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_349973.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=349973

Order

38

Type

Review Article

Type Code

2,839

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES

Details

Type

Article

Created At

25 Dec 2024