Background: The prevalence of obesity is increasing. It is regarded to be among of the world's biggest health issues and the primary factor in metabolic syndrome, a group of illnesses including hypertension, diabetes mellitus, and dyslipidemia. Many studies proved the efficacy of dietary polyphenols ascurcuminand green tea extractin ameliorating obesity and its correlated disorders.

Methods: Our work was the first to explore the impact of green tea extract and curcumin on the insulin-sensitizing anti-inflammatory adipokine C1q/ TNF-related protein-12 (CTRP-12)serum level measured by ELISA and expression of caspase-2 in white adipose tissue invivo measured by qRT-PCR.

Results: We found that both green tea extract and curcumin elevated serum CTRP-12 level. Moreover, they stimulated adipocytes apoptosis via increasing the expression of caspase-2 decreasing adiposity.

Conclusion: The current study concludes that green tea extract and curcumin have prophylactic effect against obesity and obesity-related disorders.



Keywords: high-fat diet, caspase-2, CTRP-12, green tea extract, curcumin.