337486

ASSOCIATION OF SERUM VITAMIN D-BINDING PROTEIN WITH COMPONENTS OF METABOLIC SYNDROME IN TYPE 2 DIABETIC PATIENTS IN GORGAN

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Last updated: 04 Jan 2025

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Abstract

The metabolic syndrome (MetS) is an important problem in the development of several disorders. Variations in Vitamin D binding protein (VDBP) may affect insulin secretion and glucose metabolism. This study was conducted to assess serum VDBP between MetS subjects and Type 2 diabetes mellitus (T2DM), and without MetS subjects and its association with MetS components, in Gorgan. 243 patients of T2DM were included in this study. 81 patients with MetS and vitamin D deficiency (group1), 81 patients with MetS and normal vitamin D level (group2) and 81 subjects without MetS and normal vitamin D level (group3). Adult Treatment Panel-III (ATP-III) guidelines are used to define the MetS subjects. Serum VDBP levels were significantly lower in the MetS subjects than the subjects without MetS. The triglyceride (TG) and fasting blood glucose (FBG) levels were significantly lower and higher in subjects with MetS and normal vitamin D when compared to subjects with MetS, and vitamin D deficiency. Serum VDBP levels were significantly lower in MetS subjects and vitamin D deficiency compared to subjects without MetS and normal vitamin D. There were positive and negative correlations between VDBP and FBG and TG in groups 1 and 2. It could be concluded that controlling of VDBP is an effective way for controlling MetS components in subjects with MetS. It suggests that the estimation of VDBP level in different populations appears to play an important role in evaluating and considering the relationship between VDBP and MetS components in subjects with MetS.

DOI

10.21608/bfsa.2024.216659.1774

Keywords

VDBP, Metabolic syndrome, components, Type 2 diabetes mellitus, Gorgan

Authors

First Name

Abdoljalal

Last Name

Marjani

MiddleName

-

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Golestan Province, Gorgan, Iran

Email

abdoljalal@yahoo.com

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Orcid

-

First Name

Safa Jalal Abdalsahib

Last Name

Alhasoon

MiddleName

-

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Golestan Province, Gorgan, Iran

Email

safajalal31@gmail.com

City

-

Orcid

-

First Name

Karrar Jaber Hasan

Last Name

Al-hajmee

MiddleName

-

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Golestan Province, Gorgan, Iran

Email

karrar.alshimmary1990@gmail.com

City

-

Orcid

-

First Name

Mojtaba

Last Name

Zare Ebrahimabad

MiddleName

-

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Golestan Province, Gorgan, Iran

Email

victory@yahoo.com

City

-

Orcid

-

First Name

Taghi

Last Name

Amiriani

MiddleName

-

Affiliation

Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Golestan Province, Gorgan, Iran

Email

dr_amiriani@yahoo.com

City

-

Orcid

-

Volume

47

Article Issue

1

Related Issue

47734

Issue Date

2024-06-01

Receive Date

2023-06-20

Publish Date

2024-06-01

Page Start

311

Page End

319

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_337486.html

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https://bpsa.journals.ekb.eg/service?article_code=337486

Order

21

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSOCIATION OF SERUM VITAMIN D-BINDING PROTEIN WITH COMPONENTS OF METABOLIC SYNDROME IN TYPE 2 DIABETIC PATIENTS IN GORGAN

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Article

Created At

25 Dec 2024