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335835

IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.

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Last updated: 04 Jan 2025

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Abstract

Because the oral route of drug delivery is incomparable, screening of intestinal permeability and absorption of drug candidates is a critical stage before clinical trials for time and cost reasons. Permeability assessment of drugs after oral administration have been investigated using different in-vitro approaches. Fast, reliable, and non-invasive in-vitro techniques are crucial in the early stages of the drug discovery process as primary screening tools to assess intestinal permeability of lead compounds. In-vitro techniques are either experimental based or computer assisted (in-silico) methods. Experimental methods to predict intestinal permeability of drugs are mainly partitioning based physicochemical models and direct measurement based models that depend on using laborious techniques of isolated human/animal cells or tissues. In this work, partitioning based physicochemical models that can predict a compound/drug permeability potential across intestinal membrane will be elaborated. In addition, in silico models that could be of value in scaling up feasible hit compounds and throwing away possible losers will also be overviewed.

DOI

10.21608/bfsa.2024.257301.1988

Keywords

Intestinal permeability screening, In vitro approaches, In silico models

Authors

First Name

Ahmed

Last Name

Elgendy

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia, Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Saint Joseph's University, Philadelphia, Pennsylvania, 19131, USA, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

Email

ahmed.m@bu.edu.sa

City

-

Orcid

-

First Name

Adeboye

Last Name

Adejare

MiddleName

-

Affiliation

Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Saint Joseph's University, Philadelphia, Pennsylvania, 19131, USA

Email

aadejare@sju.edu

City

Philadelphia

Orcid

-

First Name

Saleh

Last Name

Abd El-Rasoul

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

sabdulrasal@bu.edu.sa

City

Aqiq

Orcid

-

First Name

Abdullah

Last Name

Asiri

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia

Email

aasiri@bu.edu.sa

City

Aqiq

Orcid

-

Volume

47

Article Issue

1

Related Issue

47734

Issue Date

2024-06-01

Receive Date

2023-12-22

Publish Date

2024-06-01

Page Start

101

Page End

117

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 47_Issue 1_Pages 101-117.pdf

PDF . 883.5kB

Link

https://bpsa.journals.ekb.eg/article_335835.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=335835

Order

6

Type

Review Article

Type Code

2,839

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.

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Type

Article

Created At

25 Dec 2024