Beta
ManageSearchChatDiscover
327756

POTENTIAL PROTECTIVE EFFECTS OF MESNA AND VITAMIN D SEPARATELY OR CONCOMITANTLY ON CYCLOPHOSPHAMIDE INDUCED HEMORRHAGIC CYSTITIS IN RATS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Hemorrhagic cystitis (HC) is the most common adverse effect of cyclophosphamide (CP). We assessed the protective role of Mesna and vitamin D against CP induced HC. Methods: This experiment was performed on 64 rats; CON group (control), CP group (sham cyclophosphamide), M group (Mesna), CL group (low dose calcitriol), CH group (high dose calcitriol), VD group (cholecalciferol), CM group (calcitriol & Mesna), and VDM group (cholecalciferol & Mesna). Results: Mesna and vitamin D revealed a significant decrease in visceral pain score, bladder index, malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-α) levels, caspase expression, and a significant increase in total antioxidant capacity (TAC) versus the CP group. Also, the VD, CH, CM & VDM groups revealed a significant decrease in TNF-α level and caspase, microtubule-associated protein light chain 3-II (LC3-II), and sequestosome-1 (SQSTM1/p62) expression versus the M group. The CH group showed a significant increase in serum calcium versus other groups. Conclusion: Vitamin D increased the uroprotective effect of Mesna, which is attributed to its ability to restore autophagy flux

DOI

10.21608/bfsa.2023.327756

Keywords

hemorrhagic cystitis, cyclophosphamide, Mesna, calcitriol, and cholecalciferol

Authors

First Name

Mennatallah

Last Name

Elkady

MiddleName

Abdallah

Affiliation

Medical Pharmacology Department, Faculty of Medicine, Tanta university 31527, Egypt

Email

mennah.elkady@med.tanta.edu.eg

City

-

Orcid

0000-0002-2063-1606

First Name

Heba

Last Name

Mahmoud

MiddleName

A.

Affiliation

Medical Pharmacology Department, Faculty of Medicine, Tanta university 31527, Egypt

Email

hebamohsen133@gmail.com

City

-

Orcid

-

First Name

Samia

Last Name

Abou El-Seoud

MiddleName

Hussien

Affiliation

Medical Pharmacology Department, Faculty of Medicine, Tanta university 31527, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Abdel Halim

MiddleName

Saeed

Affiliation

Medical Pharmacology Department, Faculty of Medicine, Tanta university 31527, Egypt

Email

mahmoud.mohamed1@med.tanta.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-07-16

Publish Date

2023-12-01

Page Start

1,453

Page End

1,474

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1453-1474.pdf

PDF . 2.5MB

Link

https://bpsa.journals.ekb.eg/article_327756.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327756

Order

327,756

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

POTENTIAL PROTECTIVE EFFECTS OF MESNA AND VITAMIN D SEPARATELY OR CONCOMITANTLY ON CYCLOPHOSPHAMIDE INDUCED HEMORRHAGIC CYSTITIS IN RATS

Details

Type

Article

Created At

25 Dec 2024