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327634

LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES

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Last updated: 25 Dec 2024

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Abstract

Background: With the rapid increase in the use of electronic cigarettes as a prevalent form of nicotine, numerous studies have reported that their use has potentially negative health effects. Objectives: Evaluate and compare the effects of electronic cigarettes and traditional cigarettes on lung tissue. Study Design and Methodology: Twenty-five male Wistar rats were split into three groups: the EC Group was treated to e-cigarette liquid vapor, the CC Group to conventional smoke, and the control group without nicotine. Result: Significant alterations were observed in both experimental groups., including an increase in thickness of the alveolar wall, infiltration of inflammatory cells, collapsed vacuole in the wall of alveoli, and focal infiltration of lymphocytes in the wall of the bronchiole. Additionally, there was up-regulation of SODs gene expression in both groups. Conclusion: Histo-pathological analysis suggests that smoking and vaping are equally harmful to lung tissue. Real-time PCR analysis revealed significant up-regulation of SODs gene expression in conventional cigarettes and electronic cigarettes compared to the control group

DOI

10.21608/bfsa.2023.327634

Authors

First Name

Hakim

Last Name

Jebur

MiddleName

Bahlok

Affiliation

pharmacology and toxicology-collage of medicine- Wasit university

Email

hjabr@uowasit.edu.iq

City

-

Orcid

0000-0002-7392-0479

First Name

Baraa

Last Name

Al saray

MiddleName

Abd Al-Kareem

Affiliation

Department of Pharmacology, College of Medicine, Wasit University, Iraq

Email

-

City

-

Orcid

-

First Name

Hasan

Last Name

Idbeis

MiddleName

Ikareim

Affiliation

Department of Microbiology, College of Medicine, Wasit University, Iraq

Email

haldriee@uowasit.edu.iq

City

-

Orcid

-

First Name

Juheb

Last Name

Akhter

MiddleName

-

Affiliation

Department of Medical Elementology & Toxicology, School of Chemical and Life Science, Jamia Hamdard, New Delhi -110062

Email

juhebakhter@gmail.com

City

-

Orcid

-

First Name

Shekh

Last Name

Afzal

MiddleName

Mohammad

Affiliation

Department of Medical Elementology & Toxicology, School of Chemical and Life Science, Jamia Hamdard, New Delhi -110062

Email

-

City

-

Orcid

-

First Name

Naushad

Last Name

Khan

MiddleName

-

Affiliation

Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India

Email

nkhanraza@yahoo.com

City

-

Orcid

-

First Name

Khloud

Last Name

Abdelsalam

MiddleName

Gamal

Affiliation

Department of Biochemistry, Faculty of Science, Damanhour University, Egypt

Email

-

City

-

Orcid

-

First Name

Wassan

Last Name

Qadim

MiddleName

Qasim

Affiliation

Department of Microbiology, College of Medicine, Wasit University, Iraq

Email

-

City

-

Orcid

-

First Name

Ban

Last Name

Qaddorri

MiddleName

H

Affiliation

Department of Microbiology, College of Medicine, Wasit University, Iraq

Email

-

City

-

Orcid

-

First Name

Ban

Last Name

Muhaisen

MiddleName

Alaa

Affiliation

Department of Microbiology, College of Medicine, Wasit University, Iraq

Email

banalaa1122@gmail.com

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-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-06-13

Publish Date

2023-12-01

Page Start

1,429

Page End

1,440

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1429-1440.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327634.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327634

Order

327,634

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

LUNG HISTO-PATHOLOGICAL CHANGES AND SODS GENE EXPRESSION IN WISTER RATS EXPOSED TO CONVENTIONAL AND ELECTRONIC CIGARETTES

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Type

Article

Created At

25 Dec 2024