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327570

COMPARISON EFFECT OF DIFFERENT COMBINATIONS OF METFORMIN, ATORVASTATIN, CAPTOPRIL AND ASPIRIN ON OXIDATIVE STRESS MARKERS OF GASTRIC AND LIVER TISSUES OF DIABETIC RATS

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Last updated: 25 Dec 2024

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Abstract

Some recent studies have been suggested high - dose aspirin consumption in diabetic patient because of its modifying effect on metabolism of glucose and lipid. In other side many researches showed aspirin induced gastrointestinal damage. Investigation of the effect of high-dose aspirin consumption in combinations with metformin, captopril and atorvastatin on oxidative stress markers in the stomach and liver tissues of diabetic rats. Rats divided into eleven groups: control (Cont), diabetic (D), and 9 treated groups with various combination of metformin (M), atorvastatin (AT), captopril (C), and aspirin (ASA). Animals were treated orally by M, C, AT and ASA daily for 6 weeks. Finally, oxidative markers were evaluated in stomach and liver tissues. The Malondialdehyde (MDA) level significantly boosted while total thiol content remarkably decreased in the diabetic group than the control. Administration of the different combinations of C, M, AT and ASA could significantly attenuate above parameters. Combination of the metformin, aspirin, atorvastatin and captopril has more marked effects on oxidative stress reduction in the stomach and liver tissues of diabetic rats and could ameliorated probably oxidative stress induced by aspirin.

DOI

10.21608/bfsa.2023.327570

Keywords

diabetes, Stomach, Liver, aspirin, Drugs combination

Authors

First Name

Saeed

Last Name

Niazmand

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Email

niazmands@mums.ac.ir

City

-

Orcid

-

First Name

Reza

Last Name

Mohebbati

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

Email

mohebbatir@gmail.com

City

-

Orcid

-

First Name

Masoomeh

Last Name

Mirzaee

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Email

masomemirzaei99@yahoo.com

City

-

Orcid

-

First Name

Mahdiyeh

Last Name

Hedayati-Moghadam

MiddleName

-

Affiliation

Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran

Email

bio_ph85@yahoo.com

City

-

Orcid

-

First Name

Morteza

Last Name

Abadi

MiddleName

Ahmad

Affiliation

Department of Environmental Health Engineering, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran

Email

-

City

-

Orcid

-

First Name

Maryam

Last Name

Paseban

MiddleName

-

Affiliation

Innovative Medical Research Center and Department of physiology, Faculty of Medicine, Mashhad medical science Islamic Azad University, Mashhad, Iran Student research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Email

maryampaseban1400@gmail.com

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-05-01

Publish Date

2023-12-01

Page Start

1,397

Page End

1,406

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1397-1406.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327570.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327570

Order

327,570

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COMPARISON EFFECT OF DIFFERENT COMBINATIONS OF METFORMIN, ATORVASTATIN, CAPTOPRIL AND ASPIRIN ON OXIDATIVE STRESS MARKERS OF GASTRIC AND LIVER TISSUES OF DIABETIC RATS

Details

Type

Article

Created At

25 Dec 2024