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327569

COMPARATIVE ASSESSMENT OF THE PROTECTIVE EFFECT OF N-ACETYL CYSTEINE AND CAPTOPRIL AGAINST CYCLOPHOSPHAMIDE-INDUCED NEPHROTOXICITY IN WISTAR RATS

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Last updated: 25 Dec 2024

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Abstract

This work was executed to assess and compare the protective effect of n-acetyl cysteine (NAC) and captopril (CPL) in the nephrotoxicity induced by cyclophosphamide (CYP) in rats. Thirty-six adult male Wistar rats were separated into six groups (6 rats each). The control group received normal saline. NAC and CPL treated groups received NAC (200 mg/kg) and CPL (60 mg/kg) respectively for six consecutive days. Whereas CYP treated group received CYP (150 mg/kg) on the sixth day of the experiment. NAC+CYP and CPL+CYP treated groups received NAC and CPL respectively for 6 days then administered a single dose of CYP on the sixth day of the experiment. The intraperitoneal route is the method of administration of all drugs. CYP treated group showed a significant rise in levels of serum urea, creatinine, uric acid, and cystatin C, as also kidney MDA and IL-6 levels. Furthermore, it showed a significant decrease in kidney SOD, GSH, and IL-10 levels. Furthermore, the level of the Bcl2 gene was downregulated. Histopathological changes in the kidney exhibited marked tubular degenerative changes. Additionally, there was a significant increase in caspase-3 within the epithelium of the renal tubules. On the other hand, NAC+CYP and CPL+CYP treated groups protected against abnormal biochemical and histological changes and restored the Bcl2 gene. These data suggested that the administration of NAC and CPL could protect against CYP- induced nephrotoxic effect through their antioxidant, anti-inflammatory and anti-apoptotic effects

DOI

10.21608/bfsa.2023.327569

Keywords

cyclophosphamide, N-acetyl cysteine, captopril, Oxidative Stress, Gene expression, Anti-inflammatory, Nephrotoxicity

Authors

First Name

Eman

Last Name

Ali

MiddleName

Mohammed

Affiliation

Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Egypt

Email

eman.mohamed@pharm.sohag.edu.eg

City

-

Orcid

-

First Name

Walaa

Last Name

Mohammed

MiddleName

I.

Affiliation

Department of Clinical Pharmacology, Faculty of Medicine, Sohag University, Egypt

Email

walaa_mohamed@med.sohag.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-04-15

Publish Date

2023-12-01

Page Start

1,361

Page End

1,375

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1361-1375.pdf

PDF . 1.7MB

Link

https://bpsa.journals.ekb.eg/article_327569.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327569

Order

327,569

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COMPARATIVE ASSESSMENT OF THE PROTECTIVE EFFECT OF N-ACETYL CYSTEINE AND CAPTOPRIL AGAINST CYCLOPHOSPHAMIDE-INDUCED NEPHROTOXICITY IN WISTAR RATS

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Type

Article

Created At

25 Dec 2024