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327568

THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR-

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Last updated: 04 Jan 2025

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Abstract

Background:  Currently, using medicinal herbs has a great interest in the treatment of nonalcoholic fatty liver disease (NAFLD). This study evaluated the impact of stevia on the hallmark signs of dexamethasone-induced NAFLD in rats. Methods: Group I: Negative control rats received 2 ml of vehicle carboxy methyl cellulose (CMC). Group II:  Rats received dexamethasone 8 mg/kg/day intraperitoneal for 6 days. Group III: Rats received oral stevia extract 400 mg/kg/day for 12 days. Group IV: Rats received dexamethasone + stevia extract. Serum ALT, AST, TC, TG and adiponectin were measured. MDA, GPx and TNF-α were estimated in liver homogenate.  Histopathological changes and PPAR-α expressions in the liver were evaluated. Results:  Dexamethasone caused a reduction in GPx and ADP levels with an elevation in ALT, AST, TC, TG, MDA and TNF-α. There was a decrease in immunostaining expression of liver PPAR-α. Stevia caused an improvement in liver enzymes, lipid profile, oxidative stress, TNF-α and adiponectin levels. Conclusion: Stevia provided some protection against dexamethasone-induced NAFLD.

DOI

10.21608/bfsa.2023.327568

Keywords

dexamethasone, NAFLD, PPAR-α and Stevia

Authors

First Name

Mohamed

Last Name

Elbadr

MiddleName

M.

Affiliation

Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Sphinx University, New Assiut City, Assiut, Egypt

Email

mohamed.elbadre@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University,Sohag, Egypt.

Email

ph.eman.marie@gmail.com

City

-

Orcid

-

First Name

Hoda

Last Name

Elsayed

MiddleName

M.

Affiliation

Department of Histology and Cell biology, Faculty of Medicine, Sohag University, Sohag, Egypt

Email

-

City

-

Orcid

-

First Name

Mahran

Last Name

Abdel-Rahman

MiddleName

S.

Affiliation

Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt Department of Pharmacology and Toxicology, College of Pharmacy, Sphinx University, New Assiut City, Assiut, Egypt

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Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-04-06

Publish Date

2023-12-01

Page Start

1,341

Page End

1,359

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1341-1359.pdf

PDF . 1.5MB

Link

https://bpsa.journals.ekb.eg/article_327568.html

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https://bpsa.journals.ekb.eg/service?article_code=327568

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327,568

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE POTENTIAL PROTECTIVE EFFECT OF STEVIA REBAUDIANA ON DEXAMETHASONE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS: ROLE OF PPAR-

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Article

Created At

25 Dec 2024