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327619

SPIRONOLACTONE ALTERS THE LEVELS OF NEURONAL FUNCTION MARKERS IN AUTISTIC RATS

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Last updated: 25 Dec 2024

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Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by repetitive behavior and impairment in social behavior. ASD is a complex disorder with complex etiology that involves multiple genes, environmental factors, and epigenetic mechanism. Many clinical and pre-clinical study have demonstrated the association of propionic acid (PPA) with ASD. This study evaluates the potential effect of spironolactone in PPA induced ASD phenotype. PPA (250 mg/kg, po) was administered to Albino Wistar rats from post-natal day (PND) 21st to 23rd to induce ASD like neurobehavioral and neurobiochemical alterations. Animals were experimented for behavioral (elevated plus maze, three chambered social interaction apparatus, and Y-maze apparatus), biochemical parameters (BDNF, synapsin II), and blood-brain barrier impairment. Post-natal PPA exposure resulted impairment in social behavior, anxiety, and repetitive behavior in animals. Furthermore, PPA exposure caused reduction in the levels of BDNF and synapsin II in rats' brain. Spironolactone (25 mg/kg and 50 mg/kg) administration was observed to ameliorate post-natal PPA exposed behavioral and biochemical impairments in animals.

DOI

10.21608/bfsa.2023.327619

Keywords

propionic acid, autism, Spironolactone, social behavior, Repetitive Behavior, BDNF, Synapsin

Authors

First Name

Roohi

Last Name

Mirza

MiddleName

-

Affiliation

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India

Email

roohimirza2022@gmail.com

City

-

Orcid

-

First Name

Poonam

Last Name

Sharma

MiddleName

-

Affiliation

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India

Email

psharmabrain@gmail.com

City

-

Orcid

-

First Name

G

Last Name

Kulkarni

MiddleName

T.

Affiliation

Gokaraju Rangaraju College of Pharmacy, Hyderabad

Email

gtkresearch20@gmail.com

City

-

Orcid

-

First Name

Bhupesh

Last Name

Sharma

MiddleName

-

Affiliation

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India

Email

bhupeshsharmaresearch@gmail.com

City

-

Orcid

0000-0002-3423-007X

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-02-09

Publish Date

2023-12-01

Page Start

1,301

Page End

1,312

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1301-1312.pdf

PDF . 1.8MB

Link

https://bpsa.journals.ekb.eg/article_327619.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327619

Order

327,619

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPIRONOLACTONE ALTERS THE LEVELS OF NEURONAL FUNCTION MARKERS IN AUTISTIC RATS

Details

Type

Article

Created At

25 Dec 2024