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327643

IDENTICAL ANTIMICROBIAL EFFECT OF CEFTRIAXONE AND CEFOTAXIME AMONG DIFFERENT BACTERIAL ISOLATES

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Last updated: 04 Jan 2025

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Abstract

Background: This study aimed to screen the antimicrobial-resistant profile of these 3rd generation cephalosporins and to identify their similarity and interchangeability. Method: This cross-sectional study, was conducted in all the government hospitals across the Gaza Strip, Palestine. The study started in November 2017 and continued till December 2022. All clinical samples such as wound swabs (pus), urine, sputum, blood, cerebrospinal fluid (CSF), stool, and others in which ceftriaxone and cefotaxime were examined at the same time were collected from hospitalized patients and outpatient clinic attendants. After the identification of the bacterial isolates, a standard disc diffusion technique for drug susceptibility tests was performed. This study was reviewed and approved by The Palestinian Helsinki Committee. Results: In the current study, 24,120 isolates in which ceftriaxone and cefotaxime were examined at the same time were studied. The predominant organisms isolated were, Escherichia coli 9,720 (40.3%), Klebsiella spp. 5,497 (22.8%), Pseudomonas spp. 2,630 (10.9%), and Staphylococcus aureus 1941 (8.0%). Bacterial isolates showed 57.1% and 57.8% resistance against ceftriaxone and cefotaxime, respectively. In this study, 22,404 (92.9%) bacterial isolates were with identical susceptibility test results to ceftriaxone and cefotaxime. The highest match of susceptibility was seen in Acinetobacter spp. 97.3% (770/791), Klebsiella spp. 95.3% (5,241/5,491), and Escherichia coli 94.9% (9,220/9,720). In Staphylococcus aureus it was 90.6% (1,758/1,941). Conclusion: Ceftriaxone and cefotaxime can be interchangeable in most Enterobacteriaceae bacterial species. Ongoing surveillance of different bacterial antimicrobial resistance and multidrug resistance is strongly recommended together with the consideration of implementing antibiotics stewardship programs in all hospitals.

DOI

10.21608/bfsa.2023.327643

Keywords

Bacterial isolates, Bacterial resistance, cefotaxime, ceftriaxone, multidrug resistance

Authors

First Name

Khaled

Last Name

Abu El Aish

MiddleName

-

Affiliation

Pharmacy Department, Al Helal Al Emirati Hospital, Palestinnian Ministry of Health, Gaza Strip, Palestine

Email

khaledaish@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Taleb

MiddleName

H.

Affiliation

Department of Pharmacology and Medical Sciences, Faculty of Pharmacy, Al Azhar University of Gaza, Gaza Strip, Palestine

Email

mahtaleb@hotmail.com

City

-

Orcid

-

First Name

Abdel Hamid

Last Name

El Bilbeisi

MiddleName

Hassan

Affiliation

Department of Nutrition, School of Medicine and Health Sciences, University of Palestine, Gaza Strip, Palestine

Email

abed_az@hotmail.com

City

Gaza

Orcid

0000-0001-8870-8326

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-05-15

Publish Date

2023-12-01

Page Start

1,249

Page End

1,258

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1249-1258.pdf

PDF . 977.2kB

Link

https://bpsa.journals.ekb.eg/article_327643.html

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https://bpsa.journals.ekb.eg/service?article_code=327643

Order

327,643

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IDENTICAL ANTIMICROBIAL EFFECT OF CEFTRIAXONE AND CEFOTAXIME AMONG DIFFERENT BACTERIAL ISOLATES

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Type

Article

Created At

25 Dec 2024