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CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF ALLIUM SATIVUM L. ESSENTIAL OIL AGAINST MDR BACTERIA ISOLATED FROM BUCCAL CAVITY AFFECTED BY CARIES

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Last updated: 04 Jan 2025

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Abstract

Natural remedies have proven to be very effective and have fewer side effects than commercial antibiotics. The objectives of this work were to determine the chemical compounds and biological (antibacterial and antioxidant) activities of Allium sativum L. essential oil against three multi-drug strains of bacteria isolated from buccal cavity affected by caries namely Aerococcus viridans, Staphylococcus epidermidis, and S. xylosus. The essential oil was extracted by hydrodistillation, chemical compounds were quantified by gas chromatography-mass spectrometry and gas chromatography with flame ionization detection. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing power were used to study antioxidant activity. Antibacterial activity was carried out by the disk diffusion method. The average yield of the essential oil was 0.173±0.009% (w/w). All tested strains were resistant to three different classes of antibiotics. Diallyl disulfide (39.22%) and diallyl trisulfide (34.85%) were the main components of Allium sativum L. essential oils. DPPH radical scavenging assay showed the median inhibitory concentration (IC50) value of 51.12±11.77 mg/ml, while the ferric reducing power assay recorded the median effective concentration (EC50) value of 6.54 ± 0.63 mg/ml. The results showed that all multidrug-resistant bacteria strains tested are sensitive to essential oils. The results indicate that Allium sativum L. essential oil exercises good in-vitro antibacterial and weak to moderate in-vitro antioxidant activities.

DOI

10.21608/bfsa.2023.327628

Keywords

Allium sativum L, essential oil, Antibacterial activity, Antioxidant activity, multidrug-resistant bacteria

Authors

First Name

Ould

Last Name

Imane

MiddleName

Amer

Affiliation

Faculty of Life and Nature Sciences, University of Tiaret, Tiaret 14000, Algeria Laboratory of Agro-Biotechnology and Nutrition in Semi-Arid Areas, University of Tiaret, Tiaret 14000, Algeria

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Orcid

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First Name

Sidi Mohammed Ammar

Last Name

Selles

MiddleName

-

Affiliation

Institute of veterinary sciences, University of Tiaret, Tiaret 14000, Algeria

Email

nuider10@yahoo.fr

City

-

Orcid

0000-0001-8070-9981

First Name

Laaredj

Last Name

Hocine

MiddleName

-

Affiliation

Faculty of Life and Nature Sciences, University of Tiaret, Tiaret 14000, Algeria

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-

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-

Orcid

-

First Name

Dilmi

Last Name

Abdelkader

MiddleName

Bouras

Affiliation

Labotatory of natural bioressources, Université of Chlef Hassiba Benbouali, Chlef 2000, Algeria

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-

City

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Orcid

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First Name

Kadari

Last Name

Yamina

MiddleName

-

Affiliation

Labotatory of natural bioressources, Université of Chlef Hassiba Benbouali, Chlef 2000, Algeria Laboratory of Farm Animal Reproduction, University of Tiaret, Algeria

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Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-04-25

Publish Date

2023-12-01

Page Start

1,197

Page End

1,208

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1197-1208.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327628.html

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https://bpsa.journals.ekb.eg/service?article_code=327628

Order

327,628

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF ALLIUM SATIVUM L. ESSENTIAL OIL AGAINST MDR BACTERIA ISOLATED FROM BUCCAL CAVITY AFFECTED BY CARIES

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Article

Created At

25 Dec 2024