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327539

ANTIMICROBIAL AND IN VITRO CYTOTOXICITY EFFECT OF GREEN SYNTHESIZED SILVER NANOPARTICLES USING AQUEOUS LEAF EXTRACT OF SENNA HIRSUTA

Article

Last updated: 25 Dec 2024

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Abstract

In this study, we prepared silver nanoparticles (AgNPs) using an aqueous Senna hirsuta leaf extract. The AgNPs were characterized using UV visible spectrophotometer, particle size, zeta potential, energy diffraction X-ray (EDAX), Fourier transform infrared (FTIR), transmission electron microscopy (TEM) and determined antibacterial and cytotoxicity impact of the AgNPs. UV-Visible spectroscopy of Senna hirsuta leaf extract synthesized into AgNPs was carried out at various time intervals. The peak (λ max) was observed at 436–446 nm and it was broad. The particle size of the synthesized AgNPs was found 28.3 nm. The Zeta potential of AgNPs was found -4.4 mV. TEM analysis demonstrated that nanoparticles have a spherical form. According to the EDAX analysis, the extract effectively capped the AgNPs. Zone of inhibition of AgNPs were observed more than those of the extract. Silver nanoparticles demonstrated effective antimicrobial activity due to their large surface area, which allows for stronger contact with cell wall of bacteria. In vitro cytotoxicity showed that synthesized AgNPs a prominent cytotoxicity activity against MCF7 cell lines

DOI

10.21608/bfsa.2023.327539

Keywords

Green synthesis, Senna hirsuta, silver nanoparticles, antimicrobial activity, Cytotoxicity

Authors

First Name

Narahari

Last Name

Palei

MiddleName

N

Affiliation

Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, India

Email

narahari.palei@gmail.com

City

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Orcid

0000-0002-2041-1849

First Name

M.

Last Name

Bhuvana

MiddleName

P.

Affiliation

Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India

Email

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City

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Orcid

-

First Name

R.

Last Name

Jayaraman

MiddleName

-

Affiliation

Shri Venkateshwara College of Pharmacy, Ariyur, Pondicherry, India

Email

-

City

-

Orcid

-

First Name

Arghya

Last Name

Dhar

MiddleName

Kusum

Affiliation

School of Pharmacy, The Neotia University, Sarisha, West Bengal, India

Email

dhararghyakusum@gmail.com

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-03-04

Publish Date

2023-12-01

Page Start

1,185

Page End

1,195

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_327539.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327539

Order

327,539

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANTIMICROBIAL AND IN VITRO CYTOTOXICITY EFFECT OF GREEN SYNTHESIZED SILVER NANOPARTICLES USING AQUEOUS LEAF EXTRACT OF SENNA HIRSUTA

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Article

Created At

25 Dec 2024