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327554

THYME AND CUMIN NANOEMULSION AS A PROMISING ANTIMICROBIAL AGENT AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS AUREUS

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Last updated: 25 Dec 2024

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Abstract

This study aimed to compare thyme, cumin extracts, and their nanoemulsion as antibacterial on S.aureus. The methods include , preparation of aqueous, oil extract and  nanoemulsion from thyme and cumin, determination of  MIC using the resazurin microdilution method, detection of mecA and coagulase genes by PCR before and after the treatment with nanoemulsions, figuring the bacteria after treatment using TEM. the result showed that the MIC values of thymus oil 100% , thymus oil nano emulsion 20% , cumin oil 100% ,cumin oil nanoemulsion 20% ,mix oil 20% ,thymus oil 20% ,cumin oil 20%  ( 0.048, 0.156 , 1.562 ,10 , 0.625 , 0.312 , 10 ,) mg/m  respectively , mecA and coagulase genes was absent after the in vitro treatment and TEM microscope showed the bacteria with extensive damage to the cell membrane. the result showed that nanoemulsion has a higher effect on S. aureus than  essential oil alone

DOI

10.21608/bfsa.2023.327554

Keywords

Thymus, cumin, Nanoparticle, Antibacterial activity, TEM microscope

Authors

First Name

Suhair

Last Name

Siraj

MiddleName

Sh. AL.

Affiliation

Biology Department, Faculty of Science, Mustansiriyah University, Bagdad, Iraq

Email

-

City

-

Orcid

-

First Name

Wedad

Last Name

Ahmed

MiddleName

-

Affiliation

Bacteriology,Mycology and Immunology department , Faculty of veterinary medicine, Benha university

Email

wedad.ahmed@fvtm.bu.edu.eg

City

-

Orcid

-

First Name

Ashraf

Last Name

Abd El-Tawab

MiddleName

A.

Affiliation

Bacteriology, Immunology and Mycology Department, Faculty of Veterinary Medicine, Benha University, Benha, Egypt

Email

ashraf.awad@fvtm.bu.edu.eg

City

-

Orcid

0000-0002-1221-3340

First Name

Fatma

Last Name

Elhofy

MiddleName

I.

Affiliation

Bacteriology, Immunology and Mycology Department, Faculty of Veterinary Medicine, Benha University, Benha, Egypt

Email

fatma.abdlallah@fvtm.bu.edu.eg

City

-

Orcid

-

First Name

Dalia

Last Name

Elmasry

MiddleName

M.A

Affiliation

Nanomaterials Research and Synthesis Unit, Animal Health Research Institute, Agricultural Research Center (ARB), Giza, Egypt

Email

dr_daliaelmasry@ahri.gov.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-02-26

Publish Date

2023-12-01

Page Start

1,169

Page End

1,183

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1169-1183.pdf

PDF . 1.2MB

Link

https://bpsa.journals.ekb.eg/article_327554.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327554

Order

327,554

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THYME AND CUMIN NANOEMULSION AS A PROMISING ANTIMICROBIAL AGENT AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS AUREUS

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Type

Article

Created At

25 Dec 2024