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TM6SF2 RS58542926 IS LINKED TO THROMBOCYTOPENIA-RELATED ADVANCED HEPATIC FIBROSIS IN EGYPTIAN PATIENTS WITH CHRONIC HEPATITIS C

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Last updated: 25 Dec 2024

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Abstract

Thrombocytopenia in chronic hepatitis C (CHC) patients is a serious complication, which hinders starting and continuation of several invasive diagnoses and treatment protocols. This problem is multifactorial; therefore, it is important to explore host factors linked to it. Interestingly while we were investigating the association between rs58542926 polymorphism in TM6SF2 gene and both hepatic & extra hepatic changes, we found a significant association between TM6SF2 risk allele and thrombocytopenia in Egyptian CHC patients. There are 351 participants in this study. We measured gene expression of IL-6 and TNF-α in peripheral blood mononuclear cells (PBMCs) and plasma thrombopoietin (TPO) level in 20 CHC patients with advanced fibrosis. The minor allele was linked to elevated thrombocytopenia (TCP), and lower TPO levels. These findings raise concerns regarding the effect of this polymorphism on different diagnostic techniques and the outcomes of hepatitis C virus (HCV) treatment. In conclusion, we demonstrated for the first time that the occurrence of the minor allele of the rs58542926 polymorphism is associated not only with hepatic but also with extrahepatic (thrombocytopenia) alterations in CHC Egyptian patients, allowing for the use of this variant as a pharmacogenetic marker to recognize CHC patients who have a high possibility for developing late stages of liver fibrosis and extrahepatic complications.

DOI

10.21608/bfsa.2023.327700

Keywords

TM6SF2, rs58542926, hepatitis C, thrombocytopenia

Authors

First Name

Mohi

Last Name

Mohammed Abdul

MiddleName

I.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hossein

Last Name

Elbadawy

MiddleName

M.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia

Email

hossein.elbadawy@hotmail.com

City

-

Orcid

-

First Name

Adriana

Last Name

Vitiello

MiddleName

-

Affiliation

Department of Molecular Medicine, University of Padua, 35121 Padua, Italy

Email

adriana.vitiello@unipd.it

City

-

Orcid

-

First Name

Hanieh

Last Name

Ghassabian

MiddleName

-

Affiliation

Department of Molecular Medicine, University of Padua, 35121 Padua, Italy

Email

haniehghassabian@gmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Eltahir

MiddleName

M.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Elham

Last Name

Hassan

MiddleName

Ahmed

Affiliation

Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

mam_elham75@yahoo.com

City

-

Orcid

-

First Name

Abeer

Last Name

Sharaf

MiddleName

-

Affiliation

Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

sharafabeer@yahoo.com

City

-

Orcid

-

First Name

Amany

Last Name

Bekhit

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt

Email

amany_bkeet@mu.edu.eg

City

-

Orcid

-

First Name

Abo Bakr

Last Name

Ahmed

MiddleName

F.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Email

-

City

-

Orcid

-

First Name

Hany

Last Name

Ahmed

MiddleName

E.A.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia 61519, Egypt Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia

Email

heahmad@taibahu.edu.sa

City

-

Orcid

-

First Name

Mekky

Last Name

Abouzied

MiddleName

M.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt

Email

-

City

-

Orcid

-

First Name

Arianna

Last Name

Calistri

MiddleName

-

Affiliation

Department of Molecular Medicine, University of Padua, 35121 Padua, Italy

Email

arianna.calistri@unipd.it

City

-

Orcid

-

First Name

Gualtiero

Last Name

Alvisi

MiddleName

-

Affiliation

Department of Molecular Medicine, University of Padua, 35121 Padua, Italy

Email

gualtiero.alvisi@unipd.it

City

-

Orcid

-

First Name

Mostafa

Last Name

Sabry

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt

Email

phmostafa1985@azhar.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-06-05

Publish Date

2023-12-01

Page Start

1,139

Page End

1,149

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1139-1149.pdf

PDF . 981.9kB

Link

https://bpsa.journals.ekb.eg/article_327700.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327700

Order

327,700

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

TM6SF2 RS58542926 IS LINKED TO THROMBOCYTOPENIA-RELATED ADVANCED HEPATIC FIBROSIS IN EGYPTIAN PATIENTS WITH CHRONIC HEPATITIS C

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Type

Article

Created At

25 Dec 2024