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327720

DISTURBANCES IN PLASMA ALIPHATIC AND AROMATIC AMINO ACIDS METABOLOMIC PROFILES IN EGYPTIAN OBESE WOMEN

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Last updated: 25 Dec 2024

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Abstract

Background: According to the World Health Organization (WHO), Egypt ranks 18th with the highest prevalence of obesity worldwide. The impact of obesity is a result of its comorbidities rather than a direct effect. Therefore, it is of utmost importance to investigate its risk factors to establish its potential preventive strategies for future complications. This study aimed at investigating the disturbances in aliphatic and aromatic amino acids profiles in Egyptian obese women. Methods: The study comprised 85 women that were classified into 5 groups (17 each):1- healthy, 2-overweights, 3-moderate obese, 4-severe obese, 5-morbid obese. Plasma metabolomic profile of the previous amino acids was evaluated using an amino acid analyzer. Results: Compared with controls, obese subgroups had significantly stepwise higher levels in the mean plasma levels of tyrosine, total aromatic amino acids (AAA) and alanine together with significantly lower levels of leucine, isoleucine, total branched chain amino acids (BCAA), BCAA/AAA ratio and glycine. Conclusion: Multivariate regression analysis indicated that the significantly elevated circulating alanine levels were good independent predictors for identifying obese patients at risk of associated metabolic disorders. Moreover, the study suggested that AA metabolomic profile can be used as useful tools for early prediction of overweight women. Amino acids-directed regimens intervention could serve as a specific potential targeting strategy for management of obesity.

DOI

10.21608/bfsa.2023.327720

Keywords

overweight, Obesity-subgroups, Aliphatic and aromatic AA profile, prediction, Chromatography

Authors

First Name

Tahia

Last Name

Saleem

MiddleName

H.

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt

Email

tahia.saleem@yahoo.com

City

-

Orcid

-

First Name

Ragaa

Last Name

Salama

MiddleName

H M

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt

Email

r.salama@aun.edu.eg

City

-

Orcid

-

First Name

Ghada

Last Name

Mohamed

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt

Email

ghadaa1980@yahoo.com

City

-

Orcid

-

First Name

Abdel Rahman

Last Name

Abdel qawy

MiddleName

-

Affiliation

Department of biochemistry, faculty of pharmacy, University (Assiut university), Assiut, Egypt

Email

abdelrahmanhassan1811@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Radwan

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt Department of Biochemistry, Sphinx University, New Assiut City, Assiut, Egypt

Email

eman.radwan@med.au.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-05-06

Publish Date

2023-12-01

Page Start

1,121

Page End

1,137

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1121-1137.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_327720.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327720

Order

327,720

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DISTURBANCES IN PLASMA ALIPHATIC AND AROMATIC AMINO ACIDS METABOLOMIC PROFILES IN EGYPTIAN OBESE WOMEN

Details

Type

Article

Created At

25 Dec 2024