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327670

DISTURBANCES IN SOME PLASMA AMINO ACIDS METABOLOMIC PROFILES AND THEIR DERIVATIVES IN EGYPTIAN OBESE WOMEN

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Last updated: 04 Jan 2025

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Abstract

Background: Obesity is a risk factor for several lifestyle diseases such as type II diabetes, hypertension, cancer and others. Studies have shown that plasma amino acids profile may be useful for screening lifestyle diseases. This case-control study aimed at investigating disturbances in acidic, basic, neutral, sulfur-containing amino acids besides imino amino acids profiles in Egyptian obese women to reach a healthy body and to stop any future complications of overweight. Methods: A total of 85 women were enrolled in this study that were classified into 5 groups (17 persons each):1- healthy, 2-overweights, 3-moderate obese, 4-severe obese, 5-morbid obese. Plasma metabolomic profile of the previous amino acids was evaluated using amino acid analyzer. Results: A statistically significant ascending increase in the mean plasma levels of citrulline, glutamate, proline and cysteine together with significant stepwise decrease in ornithine, serine, threonine, aspartate, histidine, arginine, methionine & taurine in obese subgroups as compared to controls. Conclusion: Our results of multivariate regression analysis demonstrated that the significantly elevated circulating lysine or proline levels were the best independent predictors for recognizing obese patients at risk of associated metabolic disorders and that the plasma AA metabolomic profile can be used as important biomarkers for early prediction of overweight women. Amino acids-directed regimens intervention could have significant impact on obesity management

DOI

10.21608/bfsa.2023.327670

Keywords

Chromatography, overweight, Obesity-subgroups, Amino acids metabolomic profile, prediction

Authors

First Name

Tahia

Last Name

Saleem

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt

Email

tahia.saleem@yahoo.com

City

-

Orcid

-

First Name

Ragaa

Last Name

Salama

MiddleName

H M

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt

Email

r.salama@aun.edu.eg

City

-

Orcid

-

First Name

Ghada

Last Name

Mohamed

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt

Email

ghadaa1980@yahoo.com

City

-

Orcid

-

First Name

Abdel Rahman

Last Name

Abdel qawy

MiddleName

-

Affiliation

Department of biochemistry, faculty of pharmacy, University (Assiut university), Assiut, Egypt

Email

abdelrahmanhassan1811@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Radwan

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Assiut University, Assiut, 71515, Egypt Department of Biochemistry, Sphinx University, New Assiut City, Assiut, Egypt

Email

eman.radwan@med.au.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-05-06

Publish Date

2023-12-01

Page Start

1,103

Page End

1,120

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1103-1120.pdf

PDF . 782.8kB

Link

https://bpsa.journals.ekb.eg/article_327670.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327670

Order

327,670

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DISTURBANCES IN SOME PLASMA AMINO ACIDS METABOLOMIC PROFILES AND THEIR DERIVATIVES IN EGYPTIAN OBESE WOMEN

Details

Type

Article

Created At

25 Dec 2024