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327553

PORTULACA OLERACEA LEAVES EXTRACT ATTENUATES CYCLOPHOSPHAMIDE TOXICITY IN MICE

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Last updated: 25 Dec 2024

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Abstract

Cyclophosphamide (CTX) is a well-known broad-spectrum anticancer agent however; it has severe side effects on vital organs. Portulaca oleracea that belongs to family Portulacaceae showed promising nutritional and biomedical properties. This research aimed to estimate the effect of P. oleracea leaves extract (POLE) on CTX toxicity in male CD-1 mice. Total phenolic, flavonoids contents, total antioxidant capacity (TAC), and DPPH scavenging activity (DPPH %) were determined in POLE by phytochemical quantitative analysis. Thirty-six male CD-1 mice were divided into three groups (n=12), as negative control, CTX (200 mg/kg) injected, and CTX/POLE (200 mg/kg) injected groups. Blood samples, liver tissues and kidney tissues were collected for hematological, biochemical and histopathological investigations. The total phenolic, flavonoid content, saponin, DPPH %, and total antioxidant capacity (TAC) were 1368 µg/ml, 302 µg/ml, 0.1250 µg/g, 65%, 193 µg/ml, respectively. Treatment with POLE augmented the hematological, biochemical, and histopathological changes induced by CTX of hepatic and renal tissues. Collectively, POLE reduced the hepato-renal toxicities caused by CTX in mice by improving the antioxidants/oxidants hemostasis

DOI

10.21608/bfsa.2023.327553

Keywords

Portulaca oleracea leaves, Portulacaceae, antioxidants, phytochemicals, cyclophosphamide, hepato-renal, toxicity

Authors

First Name

Fatma

Last Name

Sarhan

MiddleName

W.

Affiliation

Nutrition and Food Science, Faculty of Specific Education, Tanta University, Egypt

Email

fatma.sarhan@sed.tanta.edu.eg

City

-

Orcid

-

First Name

Sabry

Last Name

El-Naggar

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt

Email

sabry.elnagar@science.tanta.edu.eg

City

-

Orcid

-

First Name

Karim

Last Name

El-Said

MiddleName

S.

Affiliation

Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Egypt

Email

kareem.ali@science.tanta.edu.eg

City

-

Orcid

-

First Name

Amira

Last Name

Saleh

MiddleName

M.

Affiliation

Zoology Department, Faculty of Science, Damanhur University, Egypt

Email

amira.madany@sci.dmu.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2022-11-01

Publish Date

2023-12-01

Page Start

1,067

Page End

1,076

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1067-1076.pdf

PDF . 918.5kB

Link

https://bpsa.journals.ekb.eg/article_327553.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327553

Order

327,553

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PORTULACA OLERACEA LEAVES EXTRACT ATTENUATES CYCLOPHOSPHAMIDE TOXICITY IN MICE

Details

Type

Article

Created At

25 Dec 2024