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327715

INVESTIGATING THE GENETIC EFFECT OF VKORC1 GENE POLYMORPHISM ON WARFARIN RESPONSE IN EGYPTIAN HEART PATIENTS

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Last updated: 25 Dec 2024

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Abstract

Warfarin is a common oral anticoagulant, but the dose needed for each patient can vary by as much as 20 times due to both environmental and genetic factors. Some of the most important genetic targets of warfarin include the vitamin K epoxide reductase complex 1 (VKORC1) gene. This study investigated the genetic effect of the VKORC1 gene on warfarin response using real-time PCR in a total of 100 warfarin-treated Egyptian heart patients and 40 controls. This study confirmed a genetic association of the VKORC1 SNP rs9934438 with warfarin response. The VKORC1 SNP analysis identified the presence of 26% homozygous variant (A/A), 42% heterozygous variant (A/G), and 32% wild-type variant (G/G) among patients compared to 20%, 25%, and 55% of controls. A significant difference was found between VKORC1 genotype allelic distribution in study patients and controls (P<0.05). Patients carriers of the VKORC1 genotype (A/G) required a lower daily warfarin dose than the other variants (P=0.006). The total number of patients who reached the optimal therapeutic goal of warfarin dose of 100 study patients was 19 compared to 81 ones who did not. Females required lower daily warfarin doses than males. VKORC1 gene polymorphism did not affect INR outcomes, but it was associated with a decrease in warfarin response. The VKORC1 gene polymorphism could explain the interindividual variation in warfarin response among Egyptian patients. Our findings suggest that dosing algorithms incorporating the genetic elements of the VKORC1 genotype are essential to determine warfarin dose and could optimize the therapeutic effectiveness of warfarin and minimize its adverse effects.

DOI

10.21608/bfsa.2023.327715

Keywords

Warfarin, anticoagulation, Pharmacogenomics, VKORC1, Genotyping, Egyptians

Authors

First Name

Hassan

Last Name

Donkol

MiddleName

A.

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

hassandonkol50@gmail.com

City

-

Orcid

-

First Name

Hossam

Last Name

Ali

MiddleName

H.

Affiliation

Department of Cardiology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Hosny

Last Name

Hamed

MiddleName

B.

Affiliation

Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University

Email

hosny.omran@oncology.au.edu.eg

City

-

Orcid

-

First Name

Mahran

Last Name

Abdel-Rahman

MiddleName

S.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt Department of Pharmacology, Faculty of Pharmacy, Sphinx University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Latif

MiddleName

M. M.

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

m.abdellatif@aun.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-06-05

Publish Date

2023-12-01

Page Start

1,047

Page End

1,058

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1047-1058.pdf

PDF . 669.1kB

Link

https://bpsa.journals.ekb.eg/article_327715.html

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https://bpsa.journals.ekb.eg/service?article_code=327715

Order

327,715

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INVESTIGATING THE GENETIC EFFECT OF VKORC1 GENE POLYMORPHISM ON WARFARIN RESPONSE IN EGYPTIAN HEART PATIENTS

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Article

Created At

25 Dec 2024