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327555

CAPECITABINE EFFICACY WITH ADJUVANT RADIOTHERAPY IN THE TREATMENT OF EARLY STAGE BREAST CANCER (RETROSPECTIVE STUDY)

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Last updated: 04 Jan 2025

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Abstract

Objectives: Our goal is to assess the effectiveness and toxicity of capecitabine as radio-sensatizer with adjuvant radiotherapy in breast cancer (BC) patients. Methods: On the radiation days, the patients got capecitabine 825 mg/m2 every 12 hours with a 25% dosage reduction if creatinine clearance was lower than 30 ml/min with radiation therapy of dose of 4240 cGy administered in 16 fractions at a rate of 2.65 Gy each over the course of three weeks. In addition, a boost dose of 14 Gy administered in 7 fractions was added to the lumpectomy bed. Results: Study group were evaluated at 3, 12, 24, 36, 48, and 60 months. At 3 and 12 months, 29 patients (61.7%) exhibited G1 skin hyperpigmentation. At 60-month, 3 patients (7.5%) had G2 lymphedema (p = 0.226). At 24th month, 4 patients (9.3%) had G1 telangiectasia, 5 patients (11.6%) developed G1 skin fibrosis (p = 0.001).  Moreover, one patient (2.3%) experienced a G1 cardiac event (p = 0.416). At 3 month radiation pneumonitis G1 was identified in 3 patients (6.4%) (p = 0.416). Despite the fact that 6 patients (15%) developed distant metastases, there were no instances of local recurrence. the OS rate was 85.1%. Conclusion: Adjuvant radiation combined with capecitabine is well tolerated and effective

DOI

10.21608/bfsa.2023.327555

Keywords

radio-sensitizer, Capecitabine, Efficiency, breast cancer

Authors

First Name

Rehab

Last Name

Mohamed

MiddleName

F

Affiliation

Clinical Oncology Department, Faculty of Medicine, Assiut University, Assuit, Egypt

Email

foroukrehab@aun.edu.eg

City

-

Orcid

0000-0001-7454-2580

First Name

Seham

Last Name

Ali

MiddleName

Adel

Affiliation

Radiotherapy Department, South Egypt Cancer Institute, Assiut University, Assuit, Egypt

Email

seham.20124093@med.aun.edu.eg

City

-

Orcid

-

First Name

Samir

Last Name

Eid

MiddleName

-

Affiliation

Clinical Oncology Department, Faculty of Medicine, Assiut University, Assuit, Egypt

Email

samir@aun.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-04-14

Publish Date

2023-12-01

Page Start

1,033

Page End

1,045

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 1033-1045.pdf

PDF . 744.6kB

Link

https://bpsa.journals.ekb.eg/article_327555.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327555

Order

327,555

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CAPECITABINE EFFICACY WITH ADJUVANT RADIOTHERAPY IN THE TREATMENT OF EARLY STAGE BREAST CANCER (RETROSPECTIVE STUDY)

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Article

Created At

25 Dec 2024