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327631

QUALITY ASSESSMENT OF HERBAL MEDICINAL PRODUCTS IN BENIGN PROSTATE HYPERTROPHY: CHEMICAL MARKERS AND FINGERPRINT ANALYSIS

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Last updated: 04 Jan 2025

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Abstract

Herbal products with beneficial influence on BPH have been widely used. These herbal preparations include the extracts of Serenoa repens and/or Pumpkin seed oil. Chemical markers are crucial in the quality control of herbal medicines and construct with chromatographic fingerprint a powerful tool for quality assessment. The aim of this study was to evaluate the quality of herbal formulations used to treat BPH in Syrian local market by identifying fatty acids profile and tocopherols, besides analyzing fingerprint of methanol extracts. For this purpose, GC/MS analysis has been applied. The fatty acids content was consistent with the quality requirements in four samples. α and γ tocopherols content was in agreement of previous studies between 181-875 µg/g with the exception of one sample reached 77.5 µg/g for both α and γ tocopherol. Chromatographic fingerprint revealed the shortage of ∆7 phytosterols in pumpkin seed oil samples and the presence of parabens in one of them. The absence of Luaric acid in one sample was confirmed with chromatographic fingerprint. The results have highlighted on the importance of combining active markers with chromatographic fingerprint as a suitable technique for quality evaluation of herbal products as well efficiency and safety.

DOI

10.21608/bfsa.2023.327631

Authors

First Name

Huda

Last Name

Mando

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy- Damascus University, Damascus, Syria Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Damascus University, Damascus, Syrian Arab Republic

Email

hodamandomando@hotmail.com

City

-

Orcid

-

First Name

Ahmad

Last Name

Hassan

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Damascus University, Damascus, Syrian Arab Republic

Email

aha226@gmail.com

City

-

Orcid

-

First Name

Ghassan

Last Name

Abo Chameh

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Damascus University, Damascus, Syrian Arab Republic

Email

abochameh@yahoo.com

City

-

Orcid

-

First Name

Nathalie

Last Name

Moussa

MiddleName

-

Affiliation

31Department of Pharmaceutical Chemistry and Quality Control of Medicaments, Faculty of Pharmacy, Manara University, Latakia, Syria

Email

nathalie.moussa@manara.edu.sy

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-04-28

Publish Date

2023-12-01

Page Start

983

Page End

996

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 983-996.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327631.html

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https://bpsa.journals.ekb.eg/service?article_code=327631

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327,631

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

QUALITY ASSESSMENT OF HERBAL MEDICINAL PRODUCTS IN BENIGN PROSTATE HYPERTROPHY: CHEMICAL MARKERS AND FINGERPRINT ANALYSIS

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Article

Created At

25 Dec 2024