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327630

A VALIDATED RP-HPLC METHOD FOR SEPARATION AND DETERMINATION OF ETORICOXIB AND PARACETAMOL IN BULK AND PHARMACEUTICAL DOSAGE FORM

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Last updated: 25 Dec 2024

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Abstract

Etoricoxib is a non-steroidal, anti-inflammatory drug (NSAID) and a selective inhibitor of              Cyclooxygenase 2 (COX2), which makes it safer on the gastrointestinal tract than the other NSAIDs. Given the importance of Etoricoxib's, its combination with paracetamol offers higher efficacy and fewer side effects. In addition to the popularity of this combination in the pharmaceutical industry and the diversity of its manufacturing companies, this study aims to develop a novel, precise, selective, rapid and economic assay method for the simultaneous quantitative determination of Etoricoxib and paracetamol in bulk and pharmaceutical dosage form using reverse phase HPLC. This developed method has a short run time of less than 4 minutes using a C18 column (150×4.6) mm 5μm, a mobile phase of methanol and ammonium acetate (pH =3.5) in a ratio (60:40), respectively. The elution was observed at 245 nm using a PDA detector; the retention times of paracetamol and Etoricoxib were found to be 2.493 and 3.64 min, respectively, and a resolution factor larger than 2. Linearity was established with correlation coefficient values of 0.9991, 0.9994 for both Etoricoxib and paracetamol drugs. Precision was within the relative standard deviation of less than 2% for both drugs, and the percentage recoveries were found to be 99.98% and 99.35% for paracetamol and Etoricoxib, respectively. LOD and LOQ of paracetamol were 1.4 mg/ml and 4.3 mg/ml, respectively, and 0.52 mg/ml and 1.6 mg/ml for Etoricoxib, respectively. The selectivity test results showed no interference from the tablet excipients during the separation process, which verifies that this method is easily applicable to quality control labs and pharmaceutical industries, in addition to being  fast, accurate and cost-effective.

DOI

10.21608/bfsa.2023.327630

Keywords

Etoricoxib, RP-HPLC, Assay, validation, Paracetamol, Simultaneous

Authors

First Name

Lama

Last Name

Ghazal

MiddleName

-

Affiliation

Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, Damascus university, Syria

Email

lama412.ghazal@damascusuniversity.edu.sy

City

-

Orcid

-

First Name

Mhd

Last Name

Almardini

MiddleName

Amer

Affiliation

Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, Damascus university, Syria President of Al Andalus Private University For Medical Sciences

Email

mameralmardini@gmail.com

City

-

Orcid

0000-0002-5968-5361

First Name

Iyad

Last Name

Allous

MiddleName

-

Affiliation

Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, Damascus university, Syria

Email

iyadallous@gmail.com

City

-

Orcid

0000-0002-8189-9104

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-02-16

Publish Date

2023-12-01

Page Start

969

Page End

982

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 969-982.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327630.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327630

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327,630

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

A VALIDATED RP-HPLC METHOD FOR SEPARATION AND DETERMINATION OF ETORICOXIB AND PARACETAMOL IN BULK AND PHARMACEUTICAL DOSAGE FORM

Details

Type

Article

Created At

25 Dec 2024