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327333

PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE)

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Last updated: 25 Dec 2024

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Abstract

This research seeks to analyze the Pharmacognostic, Phytochemical evaluation, Total Phenolic, Flavonoid Content, and Antioxidant activity of the leaves of Grewia bilamellata Gagnep. (G. bilamellata). This Pharmacognostic study comprises microscopic observation, leaf characteristics, phytochemical and physicochemical analyses, and total phenolic and flavonoid content. Antioxidant activity was examined using  1,1-diphenyl-2-picrylhydrazyl (DPPH) and H2O2  assays. The leaf shows anomocytic stomata, covering, glandular and stellate type of trichomes, Total phenolic and flavonoid content turned greatest in ethanolic extract (EEGB) (90.69±2.86 mg GAE/g), and (26.21 ± 1.51 mg RE/g), respectively. EEGB showed the most intense 1,1-diphenyl-2-picrylhydrazyl (DPPH) and H2O2 scavenging activity, with  IC50 59.96 and  59.24 µg/ml. Total phenolic and flavonoid contents - DPPH and H2O2 scavenging assays were positively correlated. The Invitro Antioxidant results were also correlated with the Insilico method using xanthine oxidase (XOD) and superoxide dismutase (SOD) as targets. Microscopic and physicochemical parameters are valuable for authenticating drug identification and purity. G. bilamellata is a potential perspective source of antioxidants.

DOI

10.21608/bfsa.2023.327333

Keywords

Grewia bilamellata Gagnep, antioxidant, Pharmacognostic, Insilico

Authors

First Name

Poornima

Last Name

Gurivelli

MiddleName

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Affiliation

Research Scholar, Department of Pharmacognosy, Gitam School of pharmacy, Gitam University, Visakhapatnam, Andhra Pradesh, India

Email

poornimagurivelli@gmail.com

City

-

Orcid

-

First Name

Sunitha

Last Name

Katta

MiddleName

-

Affiliation

Department of Pharmacognosy, Gitam School of pharmacy, Gitam University, visakhapatnam. Andhra Pradesh, India

Email

skatta@gitam.edu

City

-

Orcid

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Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-01-30

Publish Date

2023-12-01

Page Start

817

Page End

833

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 817-833.pdf

PDF . 2.0MB

Link

https://bpsa.journals.ekb.eg/article_327333.html

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https://bpsa.journals.ekb.eg/service?article_code=327333

Order

327,333

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PHARMACOGNOSTIC, PHYTOCHEMICAL EVALUATION, AND ANTIOXIDANT ACTIVITY OF THE LEAVES OF GREWIA BILAMELLATA GAGNEP. (TILIACEAE)

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Article

Created At

25 Dec 2024