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327332

IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY

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Last updated: 25 Dec 2024

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Abstract

The field of pharmacognosy and herbal medicine has been growing steadily over the years due to the increasing number of studies on the side effects of modern medicines and the development of new drug lines. Plants possess therapeutic properties. Gaucher disease is a rare disorder caused by a defective GBA1 gene, which encodes the acid-β-glucosidase enzyme. The molecular docking technique revealed good binding efficiency of the selected bioactive compounds from Cassia tora (C. tora) against the acid-β-glucosidase enzyme that causes GD. A computational approach was used to analyze the ADMET profiles of various phytocompounds using admetsar, protox-ii, and swissadme software. ADMET analysis revealed that Obtusifolin-2-glucoside and Cassiaside had good Health Impact Assessment  (HIA) and showed no toxic effects. Preventive measures for GD result in side effects that are inaccessible and  result in the emergence of phytocompounds with fewer toxic effects. The obtusifolin-2-glucoside and Cassiaside of C. tora exhibited good docking scores of -7.2 and -7 kcal/mol, respectively,  and could be further analyzed using molecular dynamics and in vitro studies.

DOI

10.21608/bfsa.2023.327332

Keywords

Obtusifolin-2-glucoside, Cassia tora Linn, Gaucher disease, Acid-β-glucosidases, In-silico, ADMET

Authors

First Name

Prasanth

Last Name

DSNBK

MiddleName

-

Affiliation

Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada – 520010, Andhra Pradesh, India.

Email

dsnbkprasanth@gmail.com

City

Vijayawada

Orcid

0000-0001-5028-1283

First Name

Pamula

Last Name

Bhavanam

MiddleName

Reddy

Affiliation

Department of Pharmaceutics, Nirmala College of Pharmacy, Atmakuru, AP 522503, India

Email

-

City

-

Orcid

-

First Name

Praveen

Last Name

Pasala

MiddleName

Kumar

Affiliation

Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu 515721, Andhra Pradesh, India

Email

-

City

-

Orcid

-

First Name

Siva

Last Name

Panda

MiddleName

Prasad

Affiliation

Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, UP, India

Email

-

City

-

Orcid

-

First Name

Suneetha

Last Name

Achanti

MiddleName

-

Affiliation

Department of Pharmaceutical Analysis, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India

Email

drasuneetha@gmail.com

City

-

Orcid

-

First Name

Rajiv

Last Name

Jash

MiddleName

-

Affiliation

Department of Pharmacology, Sanaka Educational Trusts group of Institution, Malandighi, Durgapur, West Bengal, India

Email

jashrajiv@gmail.com

City

-

Orcid

-

First Name

Jamullamudi

Last Name

Namratha

MiddleName

Risy

Affiliation

Department of Pharmaceutical Chemistry, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Guntur (Dt), Andhra Pradesh, India

Email

-

City

-

Orcid

-

First Name

Badithala

Last Name

Sai Kiran

MiddleName

Siva

Affiliation

Department of Pharmaceutical Sciences, Vignan Pharmacy College, Vadlamudi, Andhra Pradesh 522213, India

Email

-

City

-

Orcid

-

First Name

Katneni

Last Name

Sandeep

MiddleName

-

Affiliation

Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India

Email

-

City

-

Orcid

-

First Name

Md.

Last Name

Ayesha

MiddleName

Beebi

Affiliation

Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India

Email

-

City

-

Orcid

-

First Name

Poojitha

Last Name

Mokkapati

MiddleName

-

Affiliation

Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India

Email

poojithamokkapati@gmail.com

City

-

Orcid

-

First Name

Pavithra

Last Name

Chaganti

MiddleName

-

Affiliation

Department of Pharmacognosy, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India

Email

pavithrachowdary1211@gmail.com

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2022-12-29

Publish Date

2023-12-01

Page Start

803

Page End

815

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 803-815.pdf

PDF . 1.5MB

Link

https://bpsa.journals.ekb.eg/article_327332.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327332

Order

327,332

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN-SILICO STUDY OF CASSIA TORA LINN IN THE TREATMENT OF GAUCHER DISEASE: A SCIENTIFIC ETHNOMEDICAL STUDY

Details

Type

Article

Created At

25 Dec 2024