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327759

ADVANCEMENTS IN NANOPARTICLE-BASED RNA THERAPEUTICS AND RNA DELIVERY SYSTEMS

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Last updated: 04 Jan 2025

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Abstract

Indeed, because of their potential to overcome some of the limitations of synthetic polymer-based nanoparticles, the usage of RNA-based nanoparticles has attracted substantial interest in recent years. Because RNA is a naturally occurring molecule that can be easily synthesized and manipulated to attain certain features, it is an appealing platform for the generation of nanoparticles. Drug delivery, gene therapy, and imaging have all been investigated using RNA-based nanoparticles. One of its advantages is RNA-based nanoparticles' biocompatibility, making them less likely to produce toxicity or unfavorable effects in biological systems. Furthermore, RNA-based nanoparticles can be made to be very selective, allowing therapeutic medicines to be delivered to specific cells or tissues. This selectivity is achieved by creating RNA molecules that recognize and bind to specific targets such as cancer cells or virus particles. Because RNA-based nanoparticles are biodegradable and do not persist in the environment, they have the potential to be more environmentally friendly than synthetic polymer-based nanoparticles. As a result, the usage of RNA-based nanoparticles may lessen the potential for negative effects on aquatic and other habitats. Overall, the development of RNA-based nanoparticles has opened up new possibilities for medicinal delivery and other applications. While there are still obstacles to overcome, such as optimizing their stability and efficacy, the potential benefits of these nanoparticles make them an intriguing area of research in nanotechnology.

DOI

10.21608/bfsa.2023.327759

Keywords

RNA-based nanoparticles, Drug delivery, gene therapy, drug development

Authors

First Name

Mais

Last Name

Al-Hamdani

MiddleName

Mazin

Affiliation

Department of Pharmaceutics- College of Pharmacy - Al-Ayen University.

Email

maismazinalhamdani@gmail.com

City

-

Orcid

-

First Name

Sarmad

Last Name

noori

MiddleName

dheyaa

Affiliation

Department of Pharmaceutical Chemistry, College of Pharmacy ,Al-Ayen University

Email

sarmaddheyaa@gmail.com

City

-

Orcid

-

First Name

Amira

Last Name

kassem

MiddleName

B

Affiliation

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damnhour University Department of Clinical Pharmacy, Collage of Pharmacy, Al-Ayen University

Email

amira.kassem@pharm.dmu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-06-23

Publish Date

2023-12-01

Page Start

785

Page End

801

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 785-801.pdf

PDF . 843.1kB

Link

https://bpsa.journals.ekb.eg/article_327759.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327759

Order

327,759

Type

Review Article

Type Code

2,839

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ADVANCEMENTS IN NANOPARTICLE-BASED RNA THERAPEUTICS AND RNA DELIVERY SYSTEMS

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Article

Created At

25 Dec 2024