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327673

CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION

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Last updated: 04 Jan 2025

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Abstract

Niosomes are promising nanocarriers for ocular drug administration since they have
the potential to enhance the bioavailability and efficacy of different drugs. Meanwhile, topical gels are beneficial for the treatment of ocular inflammation as they improve corneal permeability and increase the contact time with the eye surface. The main purpose of this study was to prepare and evaluate novel niosomal gels for intraocular delivery of celecoxib. Different niosomes were prepared using different surfactants (span 60 and span 40) and cholesterol (30-50 mol %). The optimized formulation made with span 40 and cholesterol (7:3 molar ratio) has a relatively high encapsulation efficiency (~57%) with reasonable particle size for ocular delivery (~348 nm) and showed the highest release of ~65% after 24 hrs compared to other formulations. The optimized niosomal formulation was then used to prepare various formulations of celecoxib in-situ gel and topical hydrogels. The niosomal gels were well tolerated by the eye and showed similar celecoxib corneal permeation. However, the in-situ gel showed a higher anti-inflammatory effect compared to the topical hydrogel and a commercially available diclofenac eye drop. The results shown in this study indicate that celecoxib niosomal in-situ gel is a valuable drug delivery system for ocular inflammation.

DOI

10.21608/bfsa.2023.327673

Keywords

Celecoxib, Niosomes, niosomal in-situ gel, niosomal hydrogel, in-vivo anti-inflammatory effect

Authors

First Name

Mohamed

Last Name

Ahmed

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Email

mashnwny@aun.edu.eg

City

-

Orcid

-

First Name

Ikramy

Last Name

Khalil

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Email

ikramy@aun.edu.eg

City

-

Orcid

-

First Name

Khaled

Last Name

Hassanein

MiddleName

M. A.

Affiliation

Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt

Email

khaledhassanein70@yahoo.com

City

-

Orcid

-

First Name

Gamal

Last Name

El-Gendy

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Email

-

City

-

Orcid

-

First Name

Sayed

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Email

sayed.hussien@pharm.aun.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-06-15

Publish Date

2023-12-01

Page Start

757

Page End

783

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 757-783.pdf

PDF . 2.1MB

Link

https://bpsa.journals.ekb.eg/article_327673.html

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https://bpsa.journals.ekb.eg/service?article_code=327673

Order

327,673

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CELECOXIB NIOSOMAL IN-SITU GEL AS A VALUABLE DRUG DELIVERY SYSTEM FOR OCULAR INFLAMMATION

Details

Type

Article

Created At

25 Dec 2024