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327648

POLYMERIC NANOPARTICLES AS ANTICANCER DRUG DELIVERY SYSTEMS OF CERTAIN PHYTOCHEMICALS: A COMPREHENSIVE OVERVIEW

Article

Last updated: 04 Jan 2025

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Abstract

Cancer remains a major global health concern with high fatality rates despite the existing therapeutic approaches. Although chemotherapy, radiotherapy, and surgical resection have significantly lowered cancer mortality, the survival rate remains low as a result of their adverse effects, including hepatotoxicity, cardiac cytotoxicity, nephrotoxicity, gastrointestinal toxicity, myelosuppression, mucositis, neurotoxicity, and alopecia. Natural bioactive compounds (phytochemicals) have long been explored as potential reservoirs for new efficient anticancer components that can help reduce mortality rates. They exhibit extensive structural diversity and have shown promise in targeting cancer pathways, inducing cell cycle arrest, and promoting apoptosis in preclinical studies. However, their clinical application is hindered by significant limitations, including poor aqueous solubility, low bioavailability, low gastrointestinal tract stability, and rapid clearance from the bloodstream. Polymeric nanoparticles (PNPs) have emerged as a promising solution to overcome these limitations and offering efficient delivery of phytochemicals, with substantial entrapment capacity and stability, efficient controlled release, boosted bioavailability, and remarkable therapeutic efficiency. This review article provides an overview of commonly used biodegradable polymers and their classes for preparing PNPs loaded with natural phytochemicals together with their recent anticancer research findings. Moreover, this article highlights the importance of PNPs in facilitating the effective delivery of anticancer bioactive compounds, thereby enhancing their therapeutic response while reducing side effects.

DOI

10.21608/bfsa.2023.327648

Keywords

phytochemicals, Anticancer, Polymeric nanoparticles, Biodegradable polymers

Authors

First Name

Mona

Last Name

Mostafa

MiddleName

M.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Sixth of October City, Giza 12585, Egypt

Email

mona.mohammed.ph@o6u.edu.eg

City

-

Orcid

-

First Name

Maha

Last Name

Amin

MiddleName

M.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

Email

maha.amin@pharma.cu.edu.eg

City

-

Orcid

-

First Name

Shady

Last Name

M. Abd El-Halim

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, October 6 University, 6th of October City, Giza 12585, Egypt

Email

shady_mohammed@o6u.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-06-12

Publish Date

2023-12-01

Page Start

729

Page End

755

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 729-755.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_327648.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327648

Order

327,648

Type

Review Article

Type Code

2,839

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

POLYMERIC NANOPARTICLES AS ANTICANCER DRUG DELIVERY SYSTEMS OF CERTAIN PHYTOCHEMICALS: A COMPREHENSIVE OVERVIEW

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Article

Created At

25 Dec 2024