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327652

RESVERATROL LIPID BASED NANOPARTICLES SHOW A PROMISING OUTCOME ON INDUCED NON ALCOHOLIC FATTY LIVER DISEASE

Article

Last updated: 25 Dec 2024

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Abstract

Prevalence of nonalcoholic fatty liver disease (NAFLD) affects more than 25% of the populations worldwide. In this study, resveratrol loaded solid lipid nanoparticles (Res-SLNs) were prepared by emulsification and were in vitro evaluated. Res-SLN 1 containing gelucire and tween 80 was selected for further in vitro and in vivo studies. In vivo studies were done via induction of NAFLD in rats with a high fat (HF) diet for 12-weeks followed by a 6-week period of treatment with Res-SLN1. Blood samples and liver sections were taken from rats for biochemical and histological evaluations. Res-SLN1 exhibited high entrapment efficiency (75±22%), small particle size (208±48 nm) and an acceptable release rate. In vivo studies demonstrated a remarkable improvement in lipid profile and liver enzyme with Res-SLN1. The histological features were significantly improved with Res-SLN1. Res-SLNs represent a promising therapeutic approach for NAFLD via prolonging Res release and ameliorating lipid profile and liver enzymes.

DOI

10.21608/bfsa.2023.327652

Keywords

Nonalcoholic fatty liver disease, Resveratrol, Solid Lipid Nanoparticles

Authors

First Name

Dina

Last Name

Abdelmalek

MiddleName

Adel

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

dina.adel@pharm.aun.edu.eg

City

-

Orcid

-

First Name

Basma

Last Name

Abd-Elhamid

MiddleName

Nagy

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Noura

Last Name

Abd Ellah

MiddleName

Hassan

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt Department of Pharmaceutics, Faculty of Pharmacy, Badr University in Assiut, Naser city, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Sayed

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

sayed.hussien@pharm.aun.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-05-31

Publish Date

2023-12-01

Page Start

715

Page End

727

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 715-727.pdf

PDF . 1.5MB

Link

https://bpsa.journals.ekb.eg/article_327652.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327652

Order

327,652

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RESVERATROL LIPID BASED NANOPARTICLES SHOW A PROMISING OUTCOME ON INDUCED NON ALCOHOLIC FATTY LIVER DISEASE

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Article

Created At

25 Dec 2024