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327655

EVALUATION AND PREPARATION OF ATENOLOL-LOADED FLOATING MICROCAPSULES

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Last updated: 04 Jan 2025

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Abstract

The aim of this investigation is to prepare Atenolol (AT) floating microcapsules with sustained release profiles utilizing ethyl cellulose (EC) as a matrix former. EC is frequently used as a hydrophobic polymeric material for extended drug release applications. Emulsion-solvent evaporation technique was utilized to fabricate the floating microcapsules. The ratios of EC and AT utilized were 1:1, 1:2, 1:3, 1:4, and 1:5, with the amount of EC used being constant and the amount of AT being variable depending on the polymer ratio/AT ratio. The prepared microcapsules were assessed for entrapment efficiency (EE%), drug loading, percent yield (% yield), buoyancy percentage (%), particle size analysis, and in-vitro drug release study after 12 h. After that, the best-achieved microcapsule was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The best formula (M1) demonstrated a spherical morphology.  Further, M1 released about 91.23   ±   3.21%   after 12 h. Moreover, the FTIR showed that their no chemical interaction between the formulation components. In addition, DSC showed the ability of microcapsules to enclose AT inside its constructs. Further, XRD studies showed that microcapsules had an amorphous form. The previous findings demonstrated the good capability of M1 as a floating dosage form for sustained and continuous drug delivery of AT.

DOI

10.21608/bfsa.2023.327655

Keywords

atenolol, Floating dosage form, MICROCAPSULES, XRD, SEM

Authors

First Name

hayder

Last Name

hammodi

MiddleName

-

Affiliation

Department of Pharmacy Mazaya University college, Thai-Qar, Iraq

Email

hayder.hammodi@mpu.edu.iq

City

-

Orcid

-

First Name

Marwa

Last Name

El-Dahan

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University

Email

-

City

-

Orcid

-

First Name

Thanaa

Last Name

Borg

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University

Email

-

City

-

Orcid

-

Volume

46

Article Issue

2

Related Issue

44483

Issue Date

2023-12-01

Receive Date

2023-05-29

Publish Date

2023-12-01

Page Start

703

Page End

713

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 2_Pages 703-713.pdf

PDF . 808.2kB

Link

https://bpsa.journals.ekb.eg/article_327655.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=327655

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327,655

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION AND PREPARATION OF ATENOLOL-LOADED FLOATING MICROCAPSULES

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Article

Created At

25 Dec 2024