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301290

STUDY THE ANTI-INFLAMMATORY EFFECTS OF TAMSULOSIN BY THE EVALUATION OF INFLAMMATORY CELLS AND LUNG HISTOPATHOLOGY IN AN AIRWAY INFLAMMATION MODEL IN RATS

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Last updated: 25 Dec 2024

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Abstract

Objective: Study the role of tamsulosin on the respiratory inflammation in rats with ovalbumin (OVA) induced airway sensitization by evaluating the inflammatory cells in the broncho-alveolar lavage fluid (BALF) and the lung histopathology. Materials and methods: Thirty adult male albino rats were allocated into 5 groups (n=6).  Group A – Normal control (NC) fed commercial pellets and water. Group B – (as negative control) – subjected to an airway OVA-sensitization. Group C (as positive control) – treated with oral prednisolone (4.12 mg/kg) plus OVA-sensitization. Group D – treated with oral tamsulosin (35 mcg/kg/d, equivalent to 0.4 mg for a 70 kg human) plus OVA-sensitization. Group E – treated with oral tamsulosin (17.5 mcg/kg/d, equivalent to 0.2 mg tamsulosin for a 70 kg human) plus OVA-sensitization. Inflammatory cells count/µl in the BALF was calculated along with histological analysis of the lung tissue. Results: Both doses of tamsulosin (35 and 17.5 mcg/kg/d) significantly reduced the total WBC count, eosinophils, and neutrophils. A significant reduction in mononuclear cells was detected after treatment with 35 mcg/kg/d tamsulosin. Also, the histopathological examination revealed that both doses (35 and 17.5 mcg/kg/d) of tamsulosin caused less agglomeration of the inflammatory cells within the lung tissue and clear alveolar sacs. Conclusion: the administration of tamsulosin in rats with induced airway sensitization resulted in protection from respiratory inflammatory events.

DOI

10.21608/bfsa.2023.301290

Keywords

Airway inflammation, Broncho-alveolar lavage fluid, Inflammatory cells count, Ovalbumin, Tamsulosin

Authors

First Name

Hala

Last Name

Alabdali

MiddleName

H.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Iraq

Email

hala.alabdli@gmail.com

City

-

Orcid

-

First Name

Manal

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Iraq

Email

manal.ph2008@yahoo.com

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2023-01-22

Publish Date

2023-06-01

Page Start

633

Page End

645

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 633-645.pdf

PDF . 996.9kB

Link

https://bpsa.journals.ekb.eg/article_301290.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301290

Order

301,290

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

STUDY THE ANTI-INFLAMMATORY EFFECTS OF TAMSULOSIN BY THE EVALUATION OF INFLAMMATORY CELLS AND LUNG HISTOPATHOLOGY IN AN AIRWAY INFLAMMATION MODEL IN RATS

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Article

Created At

25 Dec 2024