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301261

ORLISTAT /GEMFIBROZIL AMELIORATE TESTICULAR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS VIA TARGETING VEGF/ NO / PROGRAMMED CELL DEATH FACTOR 4 SIGNALING PATHWAYS

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Last updated: 25 Dec 2024

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Abstract

One of the complex chronic consequences of diabetes is testicular dysfunction, which is well-known yet still has a murky origin. Objective: With the aim of preventing testicular dysfunction in diabetic rats, we looked into the potential effects of orlistat and gemfibrozil on vascular endothelial growth factor (VEGF) as a marker of angiogenesis, nitric oxide (NO) as an oxidative stress marker, and programmed cell death factor 4 (PDCD4) as an apoptotic marker. Methods: Streptozotocin (STZ, 40 mg/kg/i.p. once) was used to induce diabetes in adult rats, and the treated groups received treatment started one week before induction. Rats were sacrificed three weeks later, and blood samples were obtained for hormonal analysis. Additionally, testicular tissue was examined for testicular oxidative stress, inflammatory markers, and apoptotic markers. Additionally, testicular VEGF and androgen receptors were evaluated, and testicular damage was identified. Results: The results revealed a notable decrease in PDCD4 signaling along with a considerable improvement in inflammatory markers, and oxidative stress status. Conclusion: Our data highlight the significance of VEGF/NO/ PDCD4 signaling pathways in the genesis of testicular dysfunction as a consequence of diabetes mellitus and point to the positive benefits of orlistat and gemfibrozil, either separately or in combination, in reducing testicular damage in diabetic rats.

DOI

10.21608/bfsa.2023.301261

Keywords

Gemfibrozil, Orlistat, Angiogenesis, Oxidative Stress, apoptosis

Authors

First Name

Dina

Last Name

Tahoon

MiddleName

M.

Affiliation

Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt

Email

dina.tahoun@med.tanta.edu.eg

City

-

Orcid

-

First Name

Haidy

Last Name

khattab

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt

Email

haidy.khattab@med.tanta.edu.eg

City

-

Orcid

-

First Name

Elham

Last Name

Nasif

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt

Email

elham.nasif@med.tanta.edu.eg

City

-

Orcid

-

First Name

Rasha

Last Name

Elkholy

MiddleName

A.

Affiliation

Department of Clinical pathology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt

Email

rashaelkholy26@gmail.com

City

-

Orcid

-

First Name

Walaa

Last Name

Elseady

MiddleName

S.

Affiliation

Department of Anatomy, Faculty of Medicine, Tanta University, Tanta 31527, Egypt

Email

walaa.elssaidi@med.tanta.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Hamama

MiddleName

G.

Affiliation

Department of Anatomy, Faculty of Medicine, Tanta University, Tanta 31527, Egypt

Email

mohamed.hamama@med.tanta.edu.eg

City

-

Orcid

-

First Name

Sara

Last Name

Saadawy

MiddleName

F.

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig 44523, Egypt

Email

sfsaadawi@medicine.zu.edu.eg

City

-

Orcid

0000-0002-6129-3667

First Name

Reem

Last Name

ElKholy

MiddleName

A.

Affiliation

Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt / Department of pharmacology, School Of Medicine, Badr University In Cairo

Email

reem.elkholy@med.tanta.edu.eg

City

-

Orcid

0000-0003-1721-8949

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2023-01-16

Publish Date

2023-06-01

Page Start

597

Page End

614

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 597-614.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_301261.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301261

Order

301,261

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ORLISTAT /GEMFIBROZIL AMELIORATE TESTICULAR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS VIA TARGETING VEGF/ NO / PROGRAMMED CELL DEATH FACTOR 4 SIGNALING PATHWAYS

Details

Type

Article

Created At

25 Dec 2024