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301257

RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE

Article

Last updated: 25 Dec 2024

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Abstract

NAFLD is an umbrella term for a variety of illnesses of ranging severity starts with simple steatosis, develops to non-alcoholic steatohepatitis (NASH), then cirrhosis, and if not controlled, eventually can develop to fibrosis and even hepatocellular carcinoma (HCC). The disease is linked to obesity, insulin resistance, and type 2 diabetes mellitus (T2DM), thus addressing these interconnected disorders could be an effective approach for its management. This review gives an overview the most recent relevant research studies and the on-going therapeutic options for NAFLD focusing on the recently discovered sodium glucose cotransporter 2 inhibitors (SGLT2i), the new antihyperglycemic class of drugs which recently gained adequate popularity, as well as their efficacy and applications in experimental and clinical work.

DOI

10.21608/bfsa.2023.301257

Keywords

Non-alcoholic fatty liver disease, Sodium glucose co-transporter 2 inhibitors, Insulin resistance, oxidative stress

Authors

First Name

Gehan

Last Name

Heeba

MiddleName

H.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt

Email

gehan_heeba@mu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Abolnaga

MiddleName

Y.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, El-Minia, Egypt

Email

m_yehia96@hotmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Othman

MiddleName

M.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, El-Minia, Egypt

Email

eman.sholkamy@uni-wuerzburg.de

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2023-01-09

Publish Date

2023-06-01

Page Start

579

Page End

595

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 579-595.pdf

PDF . 1.2MB

Link

https://bpsa.journals.ekb.eg/article_301257.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301257

Order

301,257

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE

Details

Type

Article

Created At

25 Dec 2024