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301256

LETROZOLE ATTENUATES CARDIOMETABOLIC RISK IN PLASMODIUM BERGHEI-INFECTED MICE

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Last updated: 25 Dec 2024

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Abstract

Malaria is associated with cardiometabolic disorders, promoting the risk of cardiovascular disease (CVD). We recently demonstrated letrozole's cardioprotective effects in fructose-exposed male rats. Hence, in this study, we investigated the effect of a low-dose letrozole against cardiometabolic risk in Plasmodium berghei-infected female mice. Twenty female mice were randomly grouped into four (n=5/group): uninfected, infected, letrozole (0.24 mg/kg, p.o/day, without infection), and infected + letrozole. Weekly percentage parasitaemia was recorded. At the end of the 21-day exposure, blood and liver were collected and processed for biochemical analyses. P. berghei infection decreased serum estradiol level after 21-day infection and increased serum and liver levels of malondialdehyde, very low-density lipoprotein cholesterol, triglycerides, and triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) index. Similarly, P. berghei elevated serum uric acid and hepatic total cholesterol levels. Meanwhile, the administered dose of letrozole did not significantly affect serum estradiol but lowered lipid peroxidation, attenuated lipid alterations, and reduced serum uric acid level. We reveal that P. berghei-infection lowered serum estradiol and promoted cardiometabolic risk in female mice, while letrozole lowered parasitaemia and mitigated the associated cardiometabolic risk. Thus, this study is suggestive of letrozole's potential as an adjuvant therapy for improved management of malaria-induced cardiometabolic complications. Further study is recommended to investigate the anti-malaria potency of letrozole, independent of gender.

DOI

10.21608/bfsa.2023.301256

Keywords

Letrozole, Malaria, cardiovascular risk, cardiometabolic disorder, CVD

Authors

First Name

Adam

Last Name

Abdulkareem

MiddleName

Olaitan

Affiliation

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria/ Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India/ HOPE Cardiometabolic Research Team, University of Ilorin, Ilorin, Nigeria

Email

abdulkareem.ao@unilorin.edu.ng

City

-

Orcid

0000-0003-4850-5078

First Name

Abdulkareem

Last Name

Babamale

MiddleName

Olarewaju

Affiliation

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria/ Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan

Email

babamale.oa@unilorin.edu.ng

City

-

Orcid

-

First Name

Caleb

Last Name

Jesutomisin

MiddleName

Omisope

Affiliation

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Email

calebomisope@gmail.com

City

-

Orcid

-

First Name

Badmos-king

Last Name

Oluwabunmi

MiddleName

A

Affiliation

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Email

-

City

-

Orcid

-

First Name

Dare

Last Name

Ibiwumi

MiddleName

B

Affiliation

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Email

-

City

-

Orcid

-

First Name

Lawrence

Last Name

Olatunji

MiddleName

Aderemi

Affiliation

Cardiovascular Research Unit, Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria/ HOPE Cardiometabolic Research Team, University of Ilorin, Ilorin, Nigeria

Email

tunjilaw@unilorin.edu.ng

City

-

Orcid

-

First Name

Uade

Last Name

Ugbomoiko

MiddleName

Samuel

Affiliation

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Email

-

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-12-11

Publish Date

2023-06-01

Page Start

565

Page End

578

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 565-578.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_301256.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301256

Order

301,256

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

LETROZOLE ATTENUATES CARDIOMETABOLIC RISK IN PLASMODIUM BERGHEI-INFECTED MICE

Details

Type

Article

Created At

25 Dec 2024