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301251

CO-TREATMENT WITH CRANBERRY AND VITAMIN-C AMELIORATES THE HEPATO-RENAL TOXICITIES INDUCED BY PHENOBARBITAL IN WISTAR RATS

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Last updated: 04 Jan 2025

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Abstract

Although phenobarbital (PB) is used to treat epilepsy, its long-term treatment leads to liver and kidney dysfunctions. Natural products, however, can provide essential resources to alleviate hepato-renal toxicities due to their antioxidant's properties. This study evaluated the impact of cranberries (CB) and Vitamin-C (Vit-C) on hepato-renal toxicities induced by PB in rats. Forty male Wistar rats were allocated into five groups (N= 8) as follows: Group 1 (Gp1) was served as a negative control. Gp2 had administered with PB (160 mg/kg), orally for a month. Gp3 and Gp4 had administered with PB as in Gp2, then administered with CB (500 mg/kg) and Vit-C (27 mg/kg), respectively for a month. Gp5 had administered with PB, then administered with a combination of CB and Vit-C as in Gp3 and Gp4. Liver transaminases, albumin, total protein, creatinine, urea, total lipids, cholesterol, as well as catalase (CAT), super oxide dismutase (SOD), glutathione reduced (GSH) and malondialdehyde (MDA) were assessed. The liver and kidney histopathological alterations were examined. The treatment with PB decreased the percentage of the body weight changes, impaired the liver and kidney functions, increased the levels of total lipids, cholesterol, MDA levels, decreased the SOD, CAT activities, and changed the histological architectures of both kidney and liver. Treatment with CB or Vit-C ameliorates the adverse effects that were induced by PB, however, PB-injected rats that were co-treated with CB/Vit-C showed the highest therapeutic effects. Collectively, co-treatment with CB and Vit-C mitigated hepato-renal toxicities induced by PB-treatment in rats.

DOI

10.21608/bfsa.2023.301251

Keywords

cranberry, Vitamin-C, Phenobarbital, hepato-renal, toxicity

Authors

First Name

Sabry

Last Name

El-Naggar

MiddleName

Ali

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt

Email

sabry.elnagar@science.tanta.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Basyony

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt

Email

mbasyony@science.tanta.edu.eg

City

-

Orcid

-

First Name

Doha

Last Name

Mahmod

MiddleName

Hanafy

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt

Email

doha.hanafy@yahoo.com

City

-

Orcid

-

First Name

Heba

Last Name

Abd El-Rahman

MiddleName

Ali

Affiliation

Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt

Email

ha793481@gmail.com

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-23

Publish Date

2023-06-01

Page Start

537

Page End

550

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 537-550.pdf

PDF . 1.0MB

Link

https://bpsa.journals.ekb.eg/article_301251.html

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https://bpsa.journals.ekb.eg/service?article_code=301251

Order

301,251

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CO-TREATMENT WITH CRANBERRY AND VITAMIN-C AMELIORATES THE HEPATO-RENAL TOXICITIES INDUCED BY PHENOBARBITAL IN WISTAR RATS

Details

Type

Article

Created At

25 Dec 2024