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301249

DEPRESSION-LIKE EFFECTS OF LEVETIRACETAM WAS HALTED BY PRETREATMENT WITH N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) BLOCKERS IN MICE

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Last updated: 04 Jan 2025

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Abstract

N-methyl-D-aspartate receptor (NMDAR) stimulation might be responsible for levetiracetam -(Lev) induced depression. The aim of our study is to evaluate the effect of noncompetitive NMDAR blockers, dextromethorphan (Dxt) and dizocilpine (MK801), on Lev- induced depression in mice. Male NMRI mice were daily injected with Lev for 14 days. Pretreatments with Dxt, or MK801 were performed 30 min prior to Lev administration. The locomotor test and the forced swimming test (FST) and the novelty suppressed feeding test (NSFT) were performed. Following Dxt or MK801 pretreatment immobility time during FST was lower than Lev alone. There was no change in the locomotor activity. During NSFT, Lev increased latency, and decreased food intake; while, pretreatment with Dxt or MK801 reversed these effects. To our knowledge this is the first study showing that NMDAR blockers prevented the depressive-like behavior induced by Lev in mice. And proved that, at least in part activation of NMDAR is responsible for Lev induced depression, that warrants further research.

DOI

10.21608/bfsa.2023.301249

Keywords

Mice, depression, Epilepsy, N-methyl-D-aspartate receptors, Levetiracetam

Authors

First Name

Azadeh

Last Name

Mesripour

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Email

a_mesripour@yahoo.com

City

-

Orcid

0000-0003-3150-5581

First Name

Tanin

Last Name

Ahmadi

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Email

tanin.amdi@gmail.com

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-21

Publish Date

2023-06-01

Page Start

517

Page End

527

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 517-527.pdf

PDF . 988.9kB

Link

https://bpsa.journals.ekb.eg/article_301249.html

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https://bpsa.journals.ekb.eg/service?article_code=301249

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301,249

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DEPRESSION-LIKE EFFECTS OF LEVETIRACETAM WAS HALTED BY PRETREATMENT WITH N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) BLOCKERS IN MICE

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Article

Created At

25 Dec 2024