Beta
ManageSearchChatDiscover
301248

SHORT-TERM EFFECTS OF THE ANTI-ASTHMATIC DRUG, MONTELUKAST, IN FEMALE RATS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Asthma is a chronic disease affecting more than 300 million people worldwide. Rising asthma rates have fuelled a demand for more effort to focus on the possible effects of anti-asthma therapies. Montelukast, a leukotriene receptor antagonist was shown to be an essential mediator of asthma. It has a dual mechanism of action, acting as a bronchodilator and anti-inflammatory. However, such therapy is associated with harmful effects. This study aimed to determine the short term effects following montelukast treatment. A total of twenty female rats were assigned into two equal groups. The control group received vehicle 0.2 ml of saline solution (0.9%), while the treated group received 10 mg/kg/day of montelukast diluted in saline solution 0.9% for five consecutive days. The haematological, biochemical and histopathological analyses were studied. There were no significant differences in haematological analysis and liver enzymes compared with control group. However, there were significant reductions in the levels of total cholesterol, triglyceride and high density lipoprotein compared with control group. Also, several histopathological alterations in rat liver tissues and kidney following montelukast treatment were observed. In conclusion, montelukast has harmful effects even after short treatment periods.

DOI

10.21608/bfsa.2023.301248

Keywords

Montelukast, Haematology, histopathology, Lipid profile, Cholesterol, triglyceride

Authors

First Name

Manal

Last Name

Al-Hayder

MiddleName

N.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Iraq

Email

manal.abd-alhassan@uobasrah.edu.iq

City

-

Orcid

-

First Name

Zahra

Last Name

Almiah

MiddleName

A.

Affiliation

Department of Basra Health, Basrah, Iraq

Email

manalalhayder1911@gmail.com

City

-

Orcid

0000-0002-4548-7129

First Name

Rawaa

Last Name

Al-Mayyahi

MiddleName

S.

Affiliation

Department of Clinical Laboratory Science, College of Pharmacy, University of Basrah, Basrah, Iraq

Email

rawaa.salim@uobasrah.edu.iq

City

-

Orcid

-

First Name

Qasim

Last Name

Hussein

MiddleName

A.

Affiliation

Basrah General Hospital, Basrah, Iraq

Email

qasimit89@gmail.com

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-08-15

Publish Date

2023-06-01

Page Start

507

Page End

516

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 507-516.pdf

PDF . 1.6MB

Link

https://bpsa.journals.ekb.eg/article_301248.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301248

Order

301,248

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SHORT-TERM EFFECTS OF THE ANTI-ASTHMATIC DRUG, MONTELUKAST, IN FEMALE RATS

Details

Type

Article

Created At

25 Dec 2024