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301197

THE IMPACT OF EPITHELIAL TO MESENCHYMAL TRANSITION IN KIDNEY FIBROSIS

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Last updated: 04 Jan 2025

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Abstract

Abstract: Fibrosis is a pathological condition attributed to an inappropriate deposition of extracellular matrix that promotes scarring and  dysfunction of the implicated organ or tissue. Moreover, fibrosis encompasses an enormous range of organs and tissues, each with a distinct molecular basis. Yet, two factors are discussed: the critical function of transforming growth factor-beta (TGF-β) and the participation of the inflammatory cascade, which is required to initiate fibrotic destruction. Epithelial to mesenchymal transition (EMT), the most prevalent cellular program underlying  fibrosis, is  regulated by TGF-β, as well as other cytokines. EMT has been widely investigated, although it has not yet been adequately examined as a potential treatment option for fibrosis. A better knowledge of the linkages between fibrosis and EMT may provide an option for the establishment of a highly useful anti-fibrotic treatment. Thus, we provide a general overview of EMT; summarize the significance of TGF-β/Smad signaling cascade in EMT induction, the correlation between both EMT and renal fibrosis and the promising treatment strategies targeting fibrosis induced by EMT.

DOI

10.21608/bfsa.2023.301197

Keywords

Epithelial to mesenchymal transition, TGF-β/Smad, snail, Kidney fibrosis

Authors

First Name

Olivia

Last Name

Beshay

MiddleName

N.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Email

olivia.nady@mu.edu.eg

City

-

Orcid

0000-0003-4469-9266

First Name

Amany

Last Name

Bekhit

MiddleName

Abdlrehim

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Email

amany_bkeet@mu.edu.eg

City

-

Orcid

-

First Name

Michael

Last Name

Fawzy

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Email

michael.fawzy777@mu.edu.eg

City

-

Orcid

-

First Name

Moustafa

Last Name

Fathy

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt /Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

Email

mostafa_fathe@minia.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2023-03-06

Publish Date

2023-06-01

Page Start

497

Page End

505

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 497-505.pdf

PDF . 869.9kB

Link

https://bpsa.journals.ekb.eg/article_301197.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301197

Order

301,197

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE IMPACT OF EPITHELIAL TO MESENCHYMAL TRANSITION IN KIDNEY FIBROSIS

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Article

Created At

25 Dec 2024