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301190

OBESITY IS ASSOCIATED WITH AUTOPHAGY DYSREGULATION IN EGYPTIAN WOMEN

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Last updated: 25 Dec 2024

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Abstract

Background: Obesity causes a reduced life quality and economic burden to Egyptians. Therefore, it is of utmost importance to investigate its risk factors to establish potential preventive strategies for it and its future complications. Obesity and its associated stress insults can often interfere with the autophagic process through various mechanisms, which can result in further aggravation of obesity-related metabolic pathologies. This case control study aimed at investigating autophagy dysregulation in Egyptian obese women. Methods: This study comprised 85 women that were classified into 5 groups (17 persons each):1- healthy, 2-overweight, 3-moderate obese, 4-severe obese and 5-morbid obese group. The expression of autophagy related gene (ATG5) was estimated by qRT-PCR, whereas, the serum activity of P70S6 kinase was assayed by ELISA. Results: The data revealed elevated mRNA expression levels of ATG5 with a significantly high serum P70s 6 kinase-1 in a stepwise fashion in obese subgroups. Conclusion: The present study demonstrated increased levels of both autophagy parameters in obese women that mean autophagy dysregulation. ROC curve analysis showed that p70S6 kinase-1 is a useful biomarker for both diagnosis and prognosis of obese subgroups. On the other hand, ATG5 was able to discriminate between the severe and moderate obese women. These data may represent a possible protective value for obese women, in addition to establishing potential strategies for autophagy inhibition in obesity and in turn, alleviation of its future complications.

DOI

10.21608/bfsa.2023.301190

Keywords

obese, ATG5, P70S6 kinase-1

Authors

First Name

Tahia

Last Name

Saleem

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut university, Assiut, Egypt

Email

tahia.saleem@yahoo.com

City

-

Orcid

-

First Name

Ragaa

Last Name

M Salama

MiddleName

H

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut university, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

Mohamed

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine,Assiut university, Assiut, Egypt

Email

ghadaa1980@yahoo.com

City

-

Orcid

-

First Name

Abdel Rahman

Last Name

Qawy

MiddleName

H Abdel

Affiliation

Department of Biochemistry, faculty of pharmacy, Assiut university, Assiut, Egypt

Email

abdelrahmanhassan1811@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Radwan

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Assiut university, Assiut, Egypt/ Department of Biochemistry, Sphinx University, New Assiut City, Assiut, Egypt

Email

eman.radwan@med.au.edu.eg

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-11-18

Publish Date

2023-06-01

Page Start

483

Page End

496

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 483-496.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_301190.html

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https://bpsa.journals.ekb.eg/service?article_code=301190

Order

301,190

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

OBESITY IS ASSOCIATED WITH AUTOPHAGY DYSREGULATION IN EGYPTIAN WOMEN

Details

Type

Article

Created At

25 Dec 2024