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301186

ISCHEMIA MODIFIED ALBUMIN (IMA): A NOVEL BIOMARKER FOR THE DIAGNOSIS OF ACUTE CORONARY SYNDROME

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Last updated: 25 Dec 2024

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Abstract

Due to the high mortality rate related to Acute Coronary Syndrome (ACS), early detection is critical. In the emergency room, ischemia modified albumin (IMA) has been proposed as a helpful indicator for the diagnosis of ACS. In this study, we aimed to investigate the role of IMA for its potential in the early diagnosis of ACS in patients experiencing sudden and severe chest pain, and the influence of some variables (gender, age, hypertension, diabetes, hypertriglyceridemia, hypercholesterolemia and smoking) on its level in ACS patients. A total of 127 patients with acute chest pain were included in the study. Patients were divided into three groups: those with acute myocardial infarction (N=45), unstable angina (N=52), and non-ischemic chest pain (NICP) (N=30). Patients with ACS had a higher level of IMA compared to those with NICP. To achieve the best sensitivity (86.5%) and specificity (76.7%), the cutoff for IMA was determined to be 71.3 u/ml. Based on our results, IMA is a sensitive marker for the early diagnosis of ACS in patients presenting with symptoms of acute chest pain.

DOI

10.21608/bfsa.2023.301186

Keywords

Ischemia modified albumin, unstable angina, myocardial infarction, Acute chest pain

Authors

First Name

Aula

Last Name

Abo Saleh

MiddleName

Saker

Affiliation

Biochemistry and Microbiology Department, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Email

ola.abo.salih@gmail.com

City

Lattakia

Orcid

-

First Name

Bassem

Last Name

Marouf

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Tishreen University, Lattakia, Syria

Email

-

City

-

Orcid

-

First Name

Afraa

Last Name

Zrieki

MiddleName

-

Affiliation

Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Email

zriekiafraa@yahoo.com

City

-

Orcid

-

Volume

46

Article Issue

1

Related Issue

41495

Issue Date

2023-06-01

Receive Date

2022-10-16

Publish Date

2023-06-01

Page Start

473

Page End

481

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 46_Issue 1_Pages 473-481.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_301186.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=301186

Order

301,186

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ISCHEMIA MODIFIED ALBUMIN (IMA): A NOVEL BIOMARKER FOR THE DIAGNOSIS OF ACUTE CORONARY SYNDROME

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Article

Created At

25 Dec 2024